AUTHOR=Kunizaki Jun , Sugiura Shiro , Sakai Akira , Teshigawara Miyuki , Makino Atsushi , Takasato Yoshihiro , Matsui Teruaki , Kondo Yasuto , Ito Komei 

TITLE=Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

JOURNAL=Frontiers in Allergy

VOLUME=4

YEAR=2023

URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2023.1298137

DOI=10.3389/falgy.2023.1298137

ISSN=2673-6101

ABSTRACT=<p>Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and <italic>in vivo</italic> basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, <italic>in vivo</italic> basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.</p>