AUTHOR=Sindher Sayantani B. , Chin Andrew R. , Aghaeepour Nima , Prince Lawrence , Maecker Holden , Shaw Gary M. , Stevenson David K. , Nadeau Kari C. , Snyder Michael , Khatri Purvesh , Boyd Scott D. , Winn Virginia D. , Angst Martin S. , Chinthrajah R. Sharon TITLE=Advances and potential of omics studies for understanding the development of food allergy JOURNAL=Frontiers in Allergy VOLUME=4 YEAR=2023 URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2023.1149008 DOI=10.3389/falgy.2023.1149008 ISSN=2673-6101 ABSTRACT=

The prevalence of food allergy continues to rise globally, carrying with it substantial safety, economic, and emotional burdens. Although preventative strategies do exist, the heterogeneity of allergy trajectories and clinical phenotypes has made it difficult to identify patients who would benefit from these strategies. Therefore, further studies investigating the molecular mechanisms that differentiate these trajectories are needed. Large-scale omics studies have identified key insights into the molecular mechanisms for many different diseases, however the application of these technologies to uncover the drivers of food allergy development is in its infancy. Here we review the use of omics approaches in food allergy and highlight key gaps in knowledge for applying these technologies for the characterization of food allergy development.