AUTHOR=Petrelli Fiorella , Giannini Daiana , Bilia Silvia , Del Corso Isabella , Rocchi Valeria , Migliorini Paola , Puxeddu Ilaria 

TITLE=Efficacy and safety of omalizumab therapy in urticaria vasculitis

JOURNAL=Frontiers in Allergy

VOLUME=3

YEAR=2022

URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2022.952079

DOI=10.3389/falgy.2022.952079

ISSN=2673-6101

ABSTRACT=<p>Urticarial vasculitis (UV) is a small-vessel leukocytoclastic vasculitis characterized by different clinical manifestations ranging from long-lasting urticarial lesions to severe and potentially life-threatening multi-organ involvement. Omalizumab (OMA), anti-IgE recombinant humanized IgG1 monoclonal antibody, has been successfully used to treat few cases of severe and/or refractory UV. In this study we report our experience on 6 patients with refractory normocomplementemic UV successfully treated with anti-IgE therapy (OMA), suggesting that this biological therapy may be a safe and effective therapeutic option in UV.</p>