AUTHOR=Sonaglioni Andrea , Albini Adriana , Noonan Douglas M. , Brucato Antonio , Lombardo Michele , Santalucia Paola TITLE=A Case of Acute Pericarditis After COVID-19 Vaccination JOURNAL=Frontiers in Allergy VOLUME=2 YEAR=2021 URL=https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2021.733466 DOI=10.3389/falgy.2021.733466 ISSN=2673-6101 ABSTRACT=

A two-dose regimen of Pfizer–BioNTech COVID-19 vaccination confers 95% protection against COronaVIrus Disease 19 (COVID-19) and the safety profile is adequate. To the submission date, there were no reports in literature of acute pericarditis after BNT162b2 vaccination. However, pericarditis has been reported as a rare event associated with COVID-19 infection, which could be due to the pro-inflammatory effects of the spike protein. Recent evidence of post-vaccine myocarditis has been published. Herein we describe the case of a middle-aged healthy women who developed symptoms and signs of acute pericarditis 7–10 days after the second dose of Pfizer–BioNTech COVID-19 vaccination. Although a direct effect cannot be stated, it is important to report a potential adverse vaccine reaction effect that could be associated with the expression of SARS-CoV-2 spike protein induced from the mRNA of the vaccine.