Skip to main content

ORIGINAL RESEARCH article

Front. Agron.
Sec. Disease Management
Volume 6 - 2024 | doi: 10.3389/fagro.2024.1508794

Efficient Hydrogen peroxide reduction in Glutathione peroxidase cycle using cost-effective FeSe2 Nanospheres

Provisionally accepted
Saif Khan Saif Khan 1,2*Sundeep S Bhagwath Sundeep S Bhagwath 2Mohammad Rehan Ajmal Mohammad Rehan Ajmal 3Intikhab A Ansari Intikhab A Ansari 4Mohtashim Lohani Mohtashim Lohani 5Sanjaya Pavgada Raghunandana Sanjaya Pavgada Raghunandana 2Mohammad Luqman Mohammad Luqman 6*
  • 1 University of Hail, Ha'il, Saudi Arabia
  • 2 Department of Basic Dental and Medical Sciences, College of Dentistry, University of Ha’il, Hail, Saudi Arabia
  • 3 Physical Biochemistry Research Laboratory, Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia
  • 4 Department of General Studies, Jubail Industrial College, P. O. Box - 10099, Jubail Industrial City-31961, Saudi Arabia
  • 5 Medical Research Centre, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia
  • 6 Department of Chemical Engineering, College of Engineering, Taibah University, 4430, Yanbu, Saudi Arabia

The final, formatted version of the article will be published soon.

    Hydrogen peroxide plays a crucial role in the melanogenesis process by regulating tyrosinase activity, the key melanin-forming enzyme responsible for the browning of fruits, vegetables, and seafood. We describe how to make highly effective FeSe2 nanospheres using a one-step solvothermal process, as well as how they work as biocatalysts. We characterized the nanospheres using various techniques such as transmission electron microscopy (TEM), Energy Dispersive X-ray analysis (EDX), and Power X-ray diffraction (XRD). We plotted the Michaelis-Menten and Lineweaver-Burk graphs and calculated the Vmax and Km parameters. FeSe2 nanospheres successfully catalyzed the reduction of hydrogen peroxide to water and alcohol. We compared the excellent enzyme efficiency to a control sample and other enzymes that were already known to exist. The initial rate was 11 times higher than the control and much better than other enzymes that were already known to exist, except for those that needed expensive noble metals. These nanosphere (termed as Nanozymes) mimic enzymatic action of natural antioxidants (e.g., glutathione peroxidase (GPx) enzyme) in biological systems. FeSe2 Nanozymes appear to be a promising agent for enhancing the shelf life of fruits and Vegetable thereby reducing damage due to early Melanogenesis.

    Keywords: melanogenesis, Nanozyme, Nanosphere, antioxidant, Oxidative Stress

    Received: 09 Oct 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Khan, Bhagwath, Ajmal, Ansari, Lohani, Raghunandana and Luqman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Saif Khan, University of Hail, Ha'il, Saudi Arabia
    Mohammad Luqman, Department of Chemical Engineering, College of Engineering, Taibah University, 4430, Yanbu, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.