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SYSTEMATIC REVIEW article
Front. Aging
Sec. Aging and the Immune System
Volume 6 - 2025 | doi: 10.3389/fragi.2025.1554186
This article is part of the Research Topic Rising Stars in Aging and the Immune System: 2024 View all articles
Global Research Trends in Inflammaging from 2005 to 2024: A Bibliometric Analysis
Provisionally accepted
Beier Jiang 1
Yi-Ni Dong 2 Yu Xiong 2 Chun-Xia Jiang 1 Jun Ping 1 Qi Wu 1 Liu-Jun Xu 1 Run-Zhe Shu 1 Dan-Dan Gao 2 Sheng-Mei Zhu 1
Weidong Ye 1
Feng Zhang 1*- 1 The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, China
- 2 Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Background：Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past two decades remain lacking.Objective: To comprehensively analyze literature development trends, scientific priorities, and their evolution in the field of inflammaging from 2005 to 2024 using bibliometric analysis.Methods：Academic literature on inflammaging was retrieved from the Web of Science Core Collection. CiteSpace software was used as the bibliometric tool to analyze annual publication trends, contributing countries/regions, leading research institutions, primary journals, and keyword co-occurrence, including clustering and burst analysis in this field.Results：The study included 1,800 eligible articles, demonstrating a consistent growth in research publications over the past twenty years. The United States and Italy were the principal contributors. The University of Bologna had the highest publication. Professor Claudio Franceschi has been a leading figure in this field. Journal analysis shows that research themes predominantly focus on molecular biology/immunology and medicine/clinical fields. Keyword analysis identifies major research hotspots as "inflammaging," "Crohn's disease," "periodontitis," "immunosenescence," "skeletal muscle," "gut microbiota," and "Parkinson's disease." Emerging term analysis indicates a shift from specific inflammatory diseases to broader aging and immune modulation studies.Conclusion：This first systematic assessment of literature trends in the field of inflammaging from 2005 to 2024 reveals sustained academic growth and an increasingly deep research focus.
Keywords: Inflammaging, immunosenescence, Bibliometrics, Research hotspots, scientific trends
Received: 01 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Jiang, Dong, Xiong, Jiang, Ping, Wu, Xu, Shu, Gao, Zhu, Ye and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng Zhang, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, China
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