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MINI REVIEW article

Front. Aging
Sec. Genetics, Genomics and Epigenomics of Aging
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1514438
This article is part of the Research Topic One Health in Aging View all articles

The Role of Anti-Aging Approaches in Managing Hypogonadism in Sedentary Older Males

Provisionally accepted
Khaled A. Abdel-sater Khaled A. Abdel-sater *
  • Mutah University, Al Karak, Jordan

The final, formatted version of the article will be published soon.

    A literature search was completed for clinical and preclinical studies published in English between 2014 and 2024 related to age, sedentary life, testosterone, and anti-aging strategies.A sedentary lifestyle and low testosterone are linked to a vicious cycle. A sedentary lifestyle lowers testosterone levels, which leads to depression, exhaustion, low energy, and weakened bone and muscle strength. These effects exacerbate the detrimental consequences of aging and physical inactivity. Anti-aging techniques can prevent and treat age-related diseases, including calorie restriction, a balanced diet, regular exercise, weight control, diabetes management, and quitting smoking. Regular exercise raises total testosterone, free testosterone, and muscle steroidogenesis. In older men, testosterone replacement treatment increases bone density, cholesterol, protein synthesis, strength, erectile function, sexual desire, and general cognitive performance. However, some studies suggest dehydroepiandrosterone supplementation may provide health improvements without negative effects, potentially reversing arterial aging and reducing cardiovascular disease risk.This article evaluates the prospects for anti-aging procedures to assist in reducing the adverse effects of aging and physical inactivity in men.

    Keywords: Sedentary life, Testosterone, testosterone replacement therapy, Elderly men, Hypogonadism

    Received: 20 Oct 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Abdel-sater. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Khaled A. Abdel-sater, Mutah University, Al Karak, Jordan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.