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REVIEW article

Front. Aging
Sec. Healthy Longevity
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1495029
This article is part of the Research Topic Insights in Healthy Longevity 2023/2024 View all 3 articles

Climbing the Longevity Pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

Provisionally accepted
Anđela Martinović Anđela Martinović 1Matilde Mantovani Matilde Mantovani 2*Natalia Trpchevska Natalia Trpchevska 3*Eva Novak Eva Novak 4*Nikolay B. Milev Nikolay B. Milev 4*Leonie Bode Leonie Bode 3*Collin Y Ewald Collin Y Ewald 5Evelyne Yehudit Bischof Evelyne Yehudit Bischof 6Tobias Reichmuth Tobias Reichmuth 4*Rebecca Lapides Rebecca Lapides 7*Alexander A Navarini Alexander A Navarini 8Babak Saravi Babak Saravi 9Elisabeth Roider Elisabeth Roider 4*
  • 1 University of Milan, Milan, Italy
  • 2 Avea-Life, Zug, Switzerland
  • 3 AYUN AG, Zug, Switzerland
  • 4 Maximon AG, Zug, Switzerland
  • 5 ETH Zürich, Zurich, Zürich, Switzerland
  • 6 Shanghai University, Shanghai, Shanghai Municipality, China
  • 7 Vermont Lung Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, United States
  • 8 University Hospital of Basel, Basel, Basel-Stadt, Switzerland
  • 9 Faculty of Medicine, University of Freiburg, Freiburg, Germany

The final, formatted version of the article will be published soon.

    Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive review introduces the innovative concept of the "Longevity Pyramid." This conceptual framework delineates progressive intervention levels, providing a structured approach to understanding the diverse strategies available in longevity medicine. At the base of the Longevity Pyramid lies the level of prevention, emphasizing early detection strategies and advanced diagnostics or timely identification of potential health issues. Moving upwards, the next step involves lifestyle modifications, health-promoting behaviors, and proactive measures to delay the onset of age-related conditions. The Longevity Pyramid further explores the vast range of personalized interventions, highlighting the importance of tailoring medical approaches based on genetic predispositions, lifestyle factors, and unique health profiles, thereby optimizing interventions for maximal efficacy. These interventions aim to extend lifespan and reduce the impact and severity of age-related conditions, ensuring that additional years are characterized by vitality and well-being. By outlining these progressive levels of intervention, this review offers valuable insights into the evolving field of longevity medicine. This structured framework guides researchers and practitioners toward a nuanced strategic approach to advancing the science and practice of healthy aging.

    Keywords: Longevity, healthcare, Aging, lifestyle, Preventive Medicine, personalized medicine

    Received: 11 Sep 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Martinović, Mantovani, Trpchevska, Novak, Milev, Bode, Ewald, Bischof, Reichmuth, Lapides, Navarini, Saravi and Roider. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Matilde Mantovani, Avea-Life, Zug, Switzerland
    Natalia Trpchevska, AYUN AG, Zug, Switzerland
    Eva Novak, Maximon AG, Zug, Switzerland
    Nikolay B. Milev, Maximon AG, Zug, Switzerland
    Leonie Bode, AYUN AG, Zug, Switzerland
    Tobias Reichmuth, Maximon AG, Zug, Switzerland
    Rebecca Lapides, Vermont Lung Center, Larner College of Medicine, University of Vermont, Burlington, 05405, Vermont, United States
    Elisabeth Roider, Maximon AG, Zug, Switzerland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.