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REVIEW article

Front. Aging
Sec. Aging, Metabolism and Redox Biology
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1462569
This article is part of the Research Topic Aging and the Microbiome View all 4 articles

Can Salivary and Skin Microbiome Become a Biodetector for Aging-associated Diseases? Current Insights and Future Perspectives

Provisionally accepted
Fahrul Nurkolis Fahrul Nurkolis 1Trianna Wahyu Utami Trianna Wahyu Utami 2Aiman Idrus Alatas Aiman Idrus Alatas 3Danar Wicaksono Danar Wicaksono 4Rudy Kurniawan Rudy Kurniawan 5Satria Rafi Ratmandhika Satria Rafi Ratmandhika 6Kartika Taufani Sukarno Kartika Taufani Sukarno 6Yehezkiel Gian Pradipta Pahu Yehezkiel Gian Pradipta Pahu 6Bonglee Kim Bonglee Kim 7Trina E. Tallei Trina E. Tallei 8Raymond Tjandrawinata Raymond Tjandrawinata 9Ananto Ali Alhasyimi Ananto Ali Alhasyimi 2Reggie Surya Reggie Surya 10Helen Helen Helen Helen 11Princella Halim Princella Halim 11Adi Muradi Muhar Adi Muradi Muhar 11Rony Abdi Syahputra Rony Abdi Syahputra 11*
  • 1 Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, Indonesia
  • 2 Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Special Region of Yogyakarta, Indonesia
  • 3 University of Indonesia, Depok, West Java, Indonesia
  • 4 Gadjah Mada University, Yogyakarta, Special Region of Yogyakarta, Indonesia
  • 5 Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • 6 University of Brawijaya, Malang, East Java, Indonesia
  • 7 College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
  • 8 Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • 9 Atma Jaya Catholic University of Indonesia, Jakarta, Jakarta, Indonesia
  • 10 Bina Nusantara University, Jakarta, Jakarta, Indonesia
  • 11 University of North Sumatra, Medan, North Sumatra, Indonesia

The final, formatted version of the article will be published soon.

    Growth and aging are fundamental elements of human development. Aging is defined by a decrease in physiological activities and higher illness vulnerability. Affected by lifestyle, environmental, and hereditary elements, aging results in disorders including cardiovascular, musculoskeletal, and neurological diseases, which accounted for 16.1 million worldwide deaths in 2019. Stress-induced cellular senescence, caused by DNA damage, can reduce tissue regeneration and repair, promoting aging. The root cause of many age-related disorders is inflammation, encouraged by the senescence-associated secretory phenotype (SASP). Aging's metabolic changes and declining immune systems raise illness risk via promoting microbiome diversity. Stable, individual-specific skin and oral microbiomes are essential for both health and disease since dysbiosis is linked with periodontitis and eczema. Present from birth to death, the human microbiome, under the influence of diet and lifestyle, interacts symbiotically with the body. Poor dental health has been linked to Alzheimer's and Parkinson's diseases since oral microorganisms and systemic diseases have important interactions. Emphasizing the importance of microbiome health across the lifetime, this study reviews the understanding of the microbiome's role in aging-related diseases that can direct novel diagnosis and treatment approaches.

    Keywords: oral microbiome, Skin microbiome, age-related disease, Biodetector, Aging

    Received: 10 Jul 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Nurkolis, Utami, Alatas, Wicaksono, Kurniawan, Ratmandhika, Sukarno, Pahu, Kim, Tallei, Tjandrawinata, Alhasyimi, Surya, Helen, Halim, Muhar and Syahputra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rony Abdi Syahputra, University of North Sumatra, Medan, 20155, North Sumatra, Indonesia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.