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MINI REVIEW article

Front. Aging
Sec. Interventions in Aging
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1447370

General Control Nonderepressible 2 (GCN2) as a Therapeutic Target in Age-Related Diseases

Provisionally accepted
Özlem Altintas Akin Özlem Altintas Akin 1Michael R. MacArthur Michael R. MacArthur 2*
  • 1 ETH Zürich, Zurich, Zürich, Switzerland
  • 2 Princeton University, Princeton, New Jersey, United States

The final, formatted version of the article will be published soon.

    The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer.Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.

    Keywords: GCN2, ISR, Amino Acids, Aging, gerotherapeutic, Geroprotection, Cancer

    Received: 11 Jun 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Altintas Akin and MacArthur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Michael R. MacArthur, Princeton University, Princeton, 08544, New Jersey, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.