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ORIGINAL RESEARCH article

Front. Aging
Sec. Aging and the Immune System
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1444527
This article is part of the Research Topic Women in Aging and the Immune System: Volume 2 View all articles

Enhanced mitochondrial function in B cells from elderly Type-2 Diabetes Mellitus patients supports intrinsic inflammation

Provisionally accepted
Daniela Frasca Daniela Frasca 1*Valquiria Bueno Valquiria Bueno 2
  • 1 University of Miami, Coral Gables, United States
  • 2 Federal University of São Paulo, São Paulo, São Paulo, Brazil

The final, formatted version of the article will be published soon.

    In this paper, we measured B cell function in elderly healthy individuals (EH) and in elderly patients with Type-2 Diabetes Mellitus (T2DM, ET2DM), which are treatment-naive, as compared to healthy young (YH) individuals. Results show a higher serum inflammatory status of elderly versus young individuals, and especially of ET2DM versus EH. This status is associated with a reduced response to the seasonal influenza vaccine and with increased frequencies of the circulating pro-inflammatory B cell subset called Double Negative (DN) B cells. B cells from ET2DM patients are not only more inflammatory but also hyper-metabolic as compared to those from EH controls. The results herein are to our knowledge the first to show that T2DM superimposed on aging further increases systemic and B cell intrinsic inflammation, as well as dysfunctional humoral immunity. Our findings confirm and extend our previously published findings showing that inflammatory B cells are metabolically supported.

    Keywords: Aging, B cells, Inflammation, Metabolism, type-2 diabetes mellitus

    Received: 05 Jun 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Frasca and Bueno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Daniela Frasca, University of Miami, Coral Gables, United States

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