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BRIEF RESEARCH REPORT article

Front. Aging
Sec. Aging and the Immune System
Volume 5 - 2024 | doi: 10.3389/fragi.2024.1436346
This article is part of the Research Topic Pathogen-Induced Immunosenescence: Where do Vaccines Stand? View all 4 articles

Markers of Immunosenescence in CMV seropositive Healthy Elderly Adults

Provisionally accepted
Ivón Johanna Rodríguez Ivón Johanna Rodríguez 1,2*CARLOS A PARRA-LOPEZ CARLOS A PARRA-LOPEZ 1,3
  • 1 Faculty of Medicine, National University of Colombia, Bogota, Colombia
  • 2 Department of Human Body Movement and its Disorders, Faculty of Medicine, National University of Colombia, Bogota, Cundinamarca, Colombia
  • 3 Research Unit in Proteomics and Human Mycoses, Faculty of Sciences, Pontifical Javeriana University, Bogotá, Cundinamarca, Colombia

The final, formatted version of the article will be published soon.

    A significant increase in life expectancy has accompanied the growth of the world's population. Approximately 10% of the global population are adults over 60, and it is estimated that 2050 this figure will double. This increase in the proportion of older adults leads to a more significant burden of agerelated diseases. Immunosenescence predisposes elderly individuals to a higher incidence of infectious and chronic non-communicable diseases with higher mortality rates. Despite advances in research, it is necessary to evaluate the cellular characteristics of the aging immune system in populations with a high incidence of latent viruses such as cytomegalovirus (CMV). In this sense, this work aimed to identify senescence markers in cells of the innate and adaptive immune system in healthy older adults with CMV infection. We observed that older adults present an increase in the population of CD14+CD16+ intermediate monocytes, an expansion of CD56neg NK cells with an increase in the expression of CD57, as well as a decrease in the naïve CD4+ and CD8+ T cells, accompanied by an increased expression of senescence markers CD57 and KLRG1 in effector CD8+ T cells.

    Keywords: Immunosenescence1, T cells2, NK cells3, Monocytes4, flow cytometry5

    Received: 21 May 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Rodríguez and PARRA-LOPEZ. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ivón Johanna Rodríguez, Faculty of Medicine, National University of Colombia, Bogota, Colombia

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