AUTHOR=Mone Pasquale , de Donato Antonio , Varzideh Fahimeh , Kansakar Urna , Jankauskas Stanislovas S. , Pansini Antonella , Santulli Gaetano 

TITLE=Functional role of miR-34a in diabetes and frailty

JOURNAL=Frontiers in Aging

VOLUME=3

YEAR=2022

URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2022.949924

DOI=10.3389/fragi.2022.949924

ISSN=2673-6217

ABSTRACT=<p>Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.</p>