AUTHOR=Cadena Sandoval Marti , Heberle Alexander Martin , Rehbein Ulrike , Barile Cecilia , Ramos Pittol José Miguel , Thedieck Kathrin 

TITLE=mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

JOURNAL=Frontiers in Aging

VOLUME=2

YEAR=2021

URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2021.761333

DOI=10.3389/fragi.2021.761333

ISSN=2673-6217

ABSTRACT=<p>The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.</p>