AUTHOR=Uckun Fatih M. , Watts Justin 

TITLE=CD123-Directed Bispecific Antibodies for Targeting MDS Clones and Immunosuppressive Myeloid-Derived Suppressor Cells (MDSC) in High-Risk Adult MDS Patients

JOURNAL=Frontiers in Aging

VOLUME=2

YEAR=2021

URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2021.757276

DOI=10.3389/fragi.2021.757276

ISSN=2673-6217

ABSTRACT=<p>There is an urgent need to identify effective strategies to prevent leukemic transformation and induce sustained deep remissions in adult high-risk myelodysplastic syndrome (MDS) patients. This article discusses the clinical impact potential of bispecific antibodies (BiAB) capable of redirecting host T-cell cytotoxicity in an MHC-independent manner to malignant clones as well as immunosuppressive myeloid-derived suppressor cells (MDSC) as a new class of anti-MDS drug candidates. T-cell engaging BiAB targeting the CD123 antigen may help delay disease progression in high-risk adult MDS and potentially reduce the risk of transformation to secondary AML.</p>