BRIEF RESEARCH REPORT article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1581400
Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial
Provisionally accepted
Moeko Noguchi-Shinohara1
Kunihiko Yokoyama2
Junji Komatsu1
Kazumi Masuda1Mitsunobu Kouno3
Mitsuhiro Yoshita4
Kenjiro Ono1*- 1Kanazawa University, Kanazawa, Japan
- 2Public Central Hospital of Matto Ishikawa, Hakusan, Ishikawa, Japan
- 3Kinjo University, Hakusan, Ishikawa, Japan
- 4National Hospital Organization, Hokuriku National Hospital, Nanto, Japan
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BackgroundWe examined the efficacy of physical exercise with nutritional lectures in preventing cognitive decline among older adults.MethodsThis study included individuals aged ≥65 years who had no dementia. The intervention group underwent a physical exercise training program once a week and attended nutritional lectures once a month for 5 months. Baseline and 12-month cognitive assessments using the MCI Screen (MCIS) to measure memory performance were completed by individuals in the intervention (n = 76) and nonparticipant (n = 36) groups. The primary endpoint was changes in the memory performance index (MPI) scores of the MCIS.ResultsThe MPI score significantly increased by 1.8 in the intervention group and significantly decreased by 1.2 in the nonparticipant groups (p = 0.049). DiscussionMemory declines gradually overtime as a normal process of aging. Therefore, the decline of MPI score in the nonparticipant group is a natural change, however interestingly, the MPI scores improved in the intervention group, suggesting that the physical exercise with nutritional lectures may prevent memory function. Our results also suggest that through physical exercises and nutritional lectures, older adults might have developed exercise habits that increased their muscle weight which might have improved their cognitive function. A 5-month intervention of our physical exercise training program with nutritional lectures for older adults without dementia can improve their memory performance, especially individuals with 60s and 70s and with mild cognitive impairment.
Keywords: physical exercise, nutrition, intervention, Dementia, Mild Cognitive Impairment, cognitive decline
Received: 22 Feb 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Noguchi-Shinohara, Yokoyama, Komatsu, Masuda, Kouno, Yoshita and Ono. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kenjiro Ono, Kanazawa University, Kanazawa, Japan
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