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ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1567650
This article is part of the Research TopicThe Role of Neurogenesis in Cognitive Decline During AgingView all 3 articles
Effects of cannabidiol (CBD) treatments on age-related cognitive decline in C57 mice
Provisionally accepted
Behroo Mirza Agha1*
Merrin Monteith1Jarem Earl1Keona Ganske1
Tina Kaloa1Kelan J Mcdonald1Abigail Nixon1Maleeha Panjwani1Danika Robinson1Valeria Rusnak1Majid H Mohajerani2
Igor Kovalchuk3Nancy S Hong1
Robert James McDonald1*- 1Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
- 2Douglas Research Center, McGill University, Montreal, Ontario, Canada
- 3Department of Biological Sciences, Faculty of Arts and Science, University of Lethbridge, Lethbridge, Alberta, Canada
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Aging is associated with cognitive decline, and currently, no medications are approved to prevent it. Cannabinoids derived from cannabis sativa have emerged as promising therapeutic compounds, exhibiting neuroprotective, anti-inflammatory, and cognitive-enhancing properties. Despite their potential benefits, further research is needed to fully understand their efficacy across various conditions. This paper specifically investigates the effects of cannabidiol (CBD) on memory impairment and brain inflammation in aging mice. Fourteen-month-old C57 mice were administered CBD orally for seven months and subsequently evaluated between 19 and 21 months old using behavioural tasks sensitive to dysfunction of the perirhinal cortex, hippocampus, amygdala, as well as various brain regions important for motor control and coordination. Our findings indicate that CBD reduces inflammatory response in the brain and improves cognitive decline associated with aging.
Keywords: Aging, Age-related cogniTve decline, Cannabidiol (CBD), learning and memory, Hippocampus, inflammaton, Acetylcholine
Received: 27 Jan 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Mirza Agha, Monteith, Earl, Ganske, Kaloa, Mcdonald, Nixon, Panjwani, Robinson, Rusnak, Mohajerani, Kovalchuk, Hong and McDonald. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Behroo Mirza Agha, Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, T1K 3M4, Alberta, Canada
Robert James McDonald, Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, T1K 3M4, Alberta, Canada
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.