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REVIEW article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1562453
This article is part of the Research Topic Similarities and Differences Between Cellular and Molecular Mechanisms of Normal Brain Aging and Neurodegeneration View all 4 articles
DECODING BRAIN AGING TRAJECTORY: PREDICTIVE DISCREPANCIES, GENETIC SUSCEPTIBILITIES, AND EMERGING THERAPEUTIC STRATEGIES
Provisionally accepted
Yulia Komleva 1*
Kristina Shpiliukova 1
Nikolai Bondar 1,2
Alla B. Salmina 1
Elena Dmitrievna Osipova 3
Sergey Illarioshkin 1 Michael Piradov 1- 1 Research Center of Neurology (Russia), Moscow, Moscow Oblast, Russia
- 2 I.M. Sechenov First Moscow State Medical University, Moscow, Moscow Oblast, Russia
- 3 Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetski, Krasnoyarsk, Russia
The global extension of human lifespan has intensified the focus on aging, yet its underlying mechanisms remain inadequately understood. The article highlights aspects of genetic susceptibility to impaired brain bioenergetics, trends in age-related gene expression related to neuroinflammation and brain senescence, and the impact of stem cell exhaustion and quiescence on accelerated brain aging. We also review the accumulation of senescent cells, mitochondrial dysfunction, and metabolic disturbances as central pathological processes in aging, emphasizing how these factors contribute to inflammation and disrupt cellular competition defining the aging trajectory. Furthermore, we discuss emerging therapeutic strategies and the future potential of integrating advanced technologies to refine aging assessments. The combination of several methods including genetic analysis, neuroimaging techniques, cognitive tests and digital twins, offer a novel approach by simulating and monitoring individual health and aging trajectories, thereby providing more accurate and personalized insights. Conclusively, the accurate estimation of brain aging trajectories is crucial for understanding and managing aging processes, potentially transforming preventive and therapeutic strategies to improve health outcomes in aging populations.
Keywords: Brain aging, Neuroinflammation, individual aging trajectory, cell senescence, cell competition, delayed and accelerated aging, gene
Received: 17 Jan 2025; Accepted: 28 Feb 2025.
Copyright: © 2025 Komleva, Shpiliukova, Bondar, Salmina, Osipova, Illarioshkin and Piradov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yulia Komleva, Research Center of Neurology (Russia), Moscow, 125367, Moscow Oblast, Russia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.