
94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Aging Neurosci., 27 March 2025
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | https://doi.org/10.3389/fnagi.2025.1549615
This article is part of the Research TopicMechanisms and Interventions for Enhancing Cognitive Reserve in Aging PopulationsView all 5 articles
Background: With global and Chinese populations aging rapidly, maintaining cognitive function among middle-aged and elderly individuals has become a critical health priority. Understanding the factors influencing cognitive health is crucial for developing effective health policies and interventions.
Objectives: This study investigates the impact of social participation on cognitive function among middle-aged and elderly individuals, examining the mediating effects of depression and grandchild care. Given the potential variation in these effects across different demographic and socioeconomic groups, this study also explores subgroup differences to provide targeted policy recommendations.
Methods: Data from the 2020 China Health and Retirement Longitudinal Study (CHARLS) were used to analyze the relationship between social participation and cognitive function. Ordinary Least Squares (OLS) and stepwise regression models were employed, with robustness checks conducted using 2SLS regression.
Results: The study included 17,962 participants aged 45 and above. Baseline regression results indicate that social participation significantly enhances cognitive function (β = 0.417, p = 0.001) after adjusting for confounding factors. Subgroup analysis revealed that the cognitive benefits of social participation were more pronounced among individuals residing in the western region, those aged 60 and above, high-income groups, and rural populations. Mediation analysis showed that depression played a more substantial mediating role (β = –0.109, p = 0.001), while grandchild care exhibited a statistically significant but relatively small mediation effect (β = 0.004, p = 0.001).
Conclusion: Social participation not only directly improves cognitive function but also indirectly enhances it by reducing depression and increasing grandchild caregiving engagement among middle-aged and elderly individuals. However, while the mediating effect of grandchild care is statistically significant, its effect size remains relatively small, suggesting that its overall contribution to cognitive function should be interpreted with caution. In contrast, depression demonstrates a more substantial mediating effect, highlighting the critical role of mental health in cognitive aging. Given these findings, policy should prioritize interventions that mitigate depression as a primary pathway for enhancing cognitive function in aging populations. Expanding social participation opportunities should be a key strategy, particularly in the central and eastern regions, among individuals under 60 years old, those with lower income levels, and urban residents, to ensure equitable access to cognitive health benefits. Additionally, while grandchild caregiving may serve as a meaningful form of social engagement, its effects on cognitive function appear to be complex and context-dependent. Future research should explore the long-term impact of caregiving intensity and emotional burden on cognitive health to better inform aging policies and intergenerational support programs.
Cognitive function refers to the brain’s ability to process, store, and retrieve information, serving as a crucial indicator of individual physical and mental health as well as quality of life (Koczwara et al., 2012). With the rapid global aging trend, cognitive decline has become a pressing public health concern, particularly among middle-aged and elderly individuals. Neurodegenerative diseases such as dementia and Alzheimer’s disease are on the rise, posing significant challenges to healthcare systems worldwide (Fang et al., 2015). By 2050, it is estimated that over 130 million people globally will suffer from dementia (Di Tella et al., 2021; Fabbri et al., 2018). In China, the annual increase in dementia cases reaches 300,000, constituting a quarter of the global total and ranking first worldwide (Hendriks et al., 2021). The increasing prevalence of dementia not only affects individuals and families but also places a substantial economic burden on healthcare and social welfare systems (Lv et al., 2019; Wang, 2023). Projections indicate that by 2030, the annual treatment and care costs for dementia patients in China will reach $11.42 billion USD (Xu et al., 2017). Given the urgent need to address cognitive decline in aging populations, identifying protective factors and intervention strategies has become a critical research priority.
As the country with the largest elderly population globally, China is facing increasingly severe population aging and health challenges (Wang M. et al., 2022). To address these challenges, the Chinese government has implemented a series of aging policies to actively promote social participation among the elderly, aiming for a higher level of “Productive Aging” (Fang et al., 2020). The World Health Organization (WHO) advocates for “active aging,” emphasizing the three pillars of health, participation, and security to improve the quality of life of the elderly and mitigate the negative impacts of population aging (Bourassa et al., 2017). Within this framework, social participation is seen as an important health promotion measure, and its impact on cognitive function in the elderly has received widespread attention (Chen et al., 2024; Fu et al., 2018; Gu et al., 2024).
Social participation, defined as engagement in community activities, volunteer work, and social interactions, has been recognized as a key determinant of cognitive health among older adults (Barragán et al., 2021; Chopik, 2016; Mao et al., 2020; Sheng et al., 2024). According to the Use and Disuse Theory (Wang J. et al., 2024), cognitive abilities follow the principle of “use it or lose it,” meaning that reduced social engagement accelerates cognitive decline, whereas active participation in mentally and physically stimulating activities helps maintain cognitive function. The Cognitive Reserve Hypothesis further suggests that individuals who frequently engage in social interactions build greater cognitive resilience, enhancing neural efficiency and reducing the risk of dementia (Kremen et al., 2022). Additionally, Social Identity Theory posits that social participation fosters a sense of belonging, enhances self-esteem, and promotes emotional wellbeing, all of which contribute to better cognitive performance (Lam et al., 2020).
Despite growing evidence highlighting the cognitive benefits of social participation, research on its underlying mechanisms remains insufficiently explored (Brown et al., 2012; Su et al., 2018; Wilson et al., 2007). Prior studies suggest that the relationship between social engagement and cognitive function is not direct but rather mediated by psychological and social factors (George et al., 2020; Shah et al., 2016). Understanding these mediating pathways is essential for developing targeted interventions to promote cognitive health in aging populations.
Depression is a well-established risk factor for cognitive decline, and it may serve as a key mediator in the relationship between social participation and cognitive function (Hou et al., 2023; Kang et al., 2018). Engaging in social activities can provide emotional support, reduce loneliness, and increase feelings of self-worth, all of which help prevent or alleviate depression (Gao et al., 2023; Li et al., 2022). Conversely, social isolation has been linked to higher levels of depression, which in turn negatively affects cognitive function by impairing memory, attention, and executive functioning (Wang S. et al., 2024). Thus, depression may act as a mediating mechanism through which social participation bolsters cognitive function.
Another important factor is grandchild care, which represents a unique form of social participation, particularly in cultures that emphasize intergenerational support (Coall and Hertwig, 2010). In China, many middle-aged and elderly individuals assume caregiving responsibilities for their grandchildren, which can provide both cognitive stimulation and emotional fulfillment (Wang S. et al., 2022).
Studies suggest that moderate levels of grandchild care may enhance cognitive function by increasing daily activity levels, providing emotional engagement, and maintaining social interactions (Rafael et al., 2021). However, excessive caregiving responsibilities may lead to negative effects, as proposed by Role Strain Theory (Hughes et al., 2007). Intensive childcare duties can cause physical and psychological stress, reduce opportunities for personal leisure and exercise, and contribute to increased depressive symptoms (Zeng et al., 2021). Additionally, conflicts with younger parents over parenting styles and intergenerational differences in caregiving expectations may further contribute to psychological distress (Samuel et al., 2017). These negative outcomes can, in turn, impair cognitive function, creating a bidirectional relationship between grandchild care and cognitive health. Thus, grandchild care may serve as a mediating factor in the relationship between social participation and cognitive function, with its effects contingent on the balance between the benefits of engagement and the burdens of caregiving.
Based on these theoretical perspectives, this study seeks to clarify the complex relationships between social participation, cognitive function, depression, and grandchild care. The research aims to test the following hypotheses (Figure 1).
Hypothesis 1 (H1): Social participation is positively associated with cognitive function among middle-aged and elderly individuals.
Hypothesis 2 (H2): Depression mediates the relationship between social participation and cognitive function among middle-aged and elderly individuals.
Hypothesis 3 (H3): Grandchild care serves as a mediator in the social participation-cognitive function relationship among middle-aged and elderly individuals.
To empirically test these hypotheses, we will utilize data from the 2020 China Health and Retirement Longitudinal Study (CHARLS), a nationally representative dataset. Through constructing a theoretical model and employing Ordinary Least Squares (OLS) and stepwise regression models for empirical testing, we aim to investigate the impact of social participation on cognitive function among middle-aged and elderly individuals. Additionally, we will analyze the mediating roles of depression and grandchild care in this relationship. This research endeavors to provide insights for further implementation of strategies promoting social participation in aging populations and advancing healthy aging initiatives.
The data used in this study originates from the 2020 (wave 5) of the China Health and Retirement Longitudinal Study (CHARLS) database. CHARLS is a nationwide longitudinal survey that covers 28 provinces, municipalities, and autonomous regions in China, encompassing approximately 17,000 households and 28,000 respondents (Zhao et al., 2014). Utilizing a multistage stratified probability sampling method, the survey collected samples from middle-aged and elderly populations across different regions, urban and rural areas, and socioeconomic backgrounds. Its primary objective is to gain a deeper understanding of the social, economic, and health statuses of individuals aged 45 and above, making it highly representative of the national population. All data is accessible on the Peking University Open Research Data Platform.
In the data processing phase, this study merged individual and household-level data, initially obtaining 17,962 samples. Subsequently, samples below the age of 45 years were excluded, resulting in 17,738 remaining samples. Further exclusions were made for samples with missing variable values, as well as missing core explanatory variables, resulting in a final effective sample size of 13,858. For detailed sample selection procedures, as presented in Figure 2.
However, the 2020 CHARLS survey did not include specific items related to grandchild care. To address this limitation, we applied a retrospective data processing approach by incorporating grandchild care data from the same respondents in the 2018 CHARLS (Wave 4) and matching individuals using their unique ID numbers. A unique individual ID matching method was employed to track middle-aged and elderly respondents who reported providing grandchild care in 2018. Given that grandchild caregiving is a long-term, structured family responsibility in Chinese society, it is reasonable to assume that many of these individuals continued providing care in 2020. By leveraging this approach, we approximate grandchild care status in 2020 while maintaining a large and representative sample size.
This study selects cognitive function as the dependent variable. In the CHARLS 2020 survey, cognitive function was assessed in two dimensions: episodic memory and mental status (Xu et al., 2024). Episodic memory was evaluated using immediate word recall (0–10 points) and delayed word recall (0–10 points). Mental status assessment included three aspects: time orientation, calculation ability, and drawing ability. It evaluated the respondent’s ability to state the current date (month, day, year), day of the week, season, perform serial subtraction of seven from 100 (five times), and redraw a previously shown figure. Scores range from 0 to 11, with higher scores indicating superior mental status.
The total cognitive function score is computed as the sum of episodic memory and mental status scores, ranging from 0 to 31 points, with higher scores indicating better cognitive function.
The central explanatory variable in this study is social participation. The participants’ recent engagement in social activities over the past month was assessed, including the following: (1) visiting friends or relatives; (2) playing mahjong, chess, cards, or attending community activities; (3) providing help to non-cohabiting relatives, friends, or neighbors; (4) participating in dancing, fitness, or qigong; (5) involvement in club activities; (6) volunteering, charity work, or caregiving for non-cohabiting patients or disabled individuals; and (7) attending school or training courses. The level of social participation is determined by summing the number of social activities in which the participants engaged, with a total score ranging from 0 to 7 points.
This study considers depression and grandchild care as mediating variables. In the CHARLS 2020 survey:(1) Depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), which evaluated participants’ depressive symptoms over the past week. The scale comprises 10 self-reported items, comprising two positively worded items and eight negatively worded items. Responses range from “rarely or none of the time” to “most or all of the time,” scored from 0 to 3. Positive items are reverse-scored. Total scores range from 0 to 30, where scores ≥ 10 indicate depressive symptoms and scores < 10 indicate the absence of significant symptoms. Higher scores indicate more severe depression. (2) The concept of “grandchild care” was operationalized based on responses to the following question: “In the past year, how much time per week did you and your spouse spend taking care of children?” The aforementioned time spent represents the variable of grandchild care (Liao et al., 2021).
Based on previous literature, the control variables included in this study are categorized into individual and family levels (Chen et al., 2024; Ma et al., 2020). The variables at the individual level encompass age, gender, level of education, marital status, health status, smoking, drinking, and chronic conditions. On the other hand, the control variables at the family level include family size, family income, family consumption, and number of children. Detailed information on variable selection is provided in Table 1.
This study employs Ordinary Least Squares (OLS) to estimate the impact of social participation on cognitive function among middle-aged and elderly individuals. The specific model setup is as follows:
Stepwise regression method is used to verify the multiple mediating effects of grandchild care and depression on social participation and cognitive function among middle-aged and elderly individuals. The specific model setup is as follows:
Note: mmsei represents an individual’s cognitive function, socialnumi represents an individual’s social participation situation, caretimei represents an individual’s grandchild care situation, cesdi represents the level of depression in an individual, i denotes different individuals, controli represents controlling variables, εi represents random error, β0,β1,β2,βn represents estimating coefficients.
This study has been approved by the Peking University Biomedical Ethics Committee (IRB00001052-11015), and informed consent has been obtained from all participants.
Table 2 presents descriptive statistics for each variable. (i) Dependent and Independent Variables: The mean cognitive function score among the middle-aged and elderly individuals is 15.743, indicating a moderate level. The core independent variable, social participation, exhibits a mean of 0.786 and a standard deviation of 1.004. Approximately 49.15% of the middle-aged and elderly participated in social activities in the past month, indicating an overall positive attitude toward social participation among the sample, albeit with limited types of social activities. (ii) Sample Personal-Level Variables: The mean age of the sample is 61.104 years, with a gender ratio of 0.473. The mean number of years of education is 4.85, while 86% of respondents are married/cohabiting. The average self-reported health status is 3.046, with 81.3% reporting at least one chronic condition. These figures suggest a relatively low educational level and widespread health concerns among the sample. (iii) Sample Family-Level Variables: The average household size is 2.515 individuals, with 2.504 children per household. Mean household income and expenditure are 9.226 and 10.354, respectively, indicating economic pressures that may impact cognitive function.
To verify multicollinearity among explanatory and control variables, a variance inflation factor (VIF) test was conducted. All VIF values remained below 10, indicating no multicollinearity concerns. Thus, variable selection in this study is statistically appropriate (Table 3).
Table 4 presents the baseline regression results on the impact of social participation on cognitive function among middle-aged and elderly individuals (Equation 1).
Model 1 shows that without control variables, social participation significantly enhances cognitive function, with an increase of one type of social activity linked to a 1.250-point rise in cognitive function scores. Model 2 and 3, which introduce individual and family-level control variables, confirm that the positive effect remains highly significant at the 1% level. This finding underscores the robust association between social participation and cognitive function, suggesting that engagement in social activities meaningfully contributes to cognitive wellbeing in aging populations.
Individual-Level Influences on Cognitive Function: Age exhibits a significant negative effect on cognitive function. As individuals age, there are physiological changes in brain structure and function occur, including neuronal loss, slowed synaptic transmission, and diminished neuroprotective mechanisms. These changes contribute to declines in memory, slower thinking, and reduced cognitive processing speed, thereby adversely affecting cognitive function in this demographic (Shu et al., 2021). Higher education levels are positively associated with cognitive function. Higher levels of educational attainment provide individuals with a greater range of cognitive stimulation and learning experiences, which in turn facilitate enhanced information processing abilities and cognitive flexibility, thereby slowing the rate of cognitive decline (Wang Y. et al., 2024). Married/cohabiting middle - aged and elderly people tend to have better cognitive function, perhaps due to stable marital relationships, more social support, and better mental wellbeing (Van Bogart et al., 2024). Certain chronic conditions such as diabetes and cardiovascular diseases may also have a positive impact on cognitive function, potentially influencing brain health through various pathways (Shu et al., 2024; Tarraf et al., 2020). Furthermore, there is evidence to suggest that moderate long-term alcohol consumption is associated with enhanced cognitive function. This effect may be attributed to the elevation of brain-derived neurotrophic factor levels by moderate alcohol intake, along with the positive effects of certain alcohol compounds on neuroprotection and cardiovascular health (Zhang et al., 2020).
Family-Level Influences on Cognitive Function: Larger household size and more children negatively correlate with cognitive function. Resource dispersion, increased family responsibilities, and psychological strain may contribute to cognitive decline (Du et al., 2023; Yang et al., 2022). Higher household income and expenditure positively impact cognitive function. Better financial security enhances access to healthcare, nutritious diets, and cognitively stimulating activities, thereby promoting cognitive resilience (Kim and Lee, 2019; Liu et al., 2022; Shi et al., 2023).
The promoting effect of social participation on cognitive function among middle-aged and elderly individuals may exhibit heterogeneity across sample characteristics. This study employed grouped regressions based on different geographical regions, age groups, household incomes, and urban-rural divides to further examine the differential impact of social participation on cognitive function among different groups. The results are presented in Table 5.
Regional Heterogeneity Analysis: Social participation significantly enhances cognitive function across all regions, with the strongest effect observed in western China. This may be attributed to the region’s lower socioeconomic development and slower pace of life, which provide more opportunities for social engagement and emotional support. Furthermore, strong cultural traditions emphasizing community and family cohesion may further facilitate participation in social activities, thereby amplifying its cognitive benefits (Everly et al., 2023; Kelly et al., 2017).
Age Heterogeneity Analysis: Dividing the sample into middle-aged (45–59 years) and elderly (60+ years) groups reveals that social participation benefits both, with a more pronounced effect among the elderly. Cognitive decline is more prevalent with aging, and social participation provides essential cognitive stimulation, helping mitigate this decline. Additionally, post-retirement engagement in social activities helps fill social gaps, fostering continued cognitive engagement (Posis et al., 2024; Richards et al., 2019).
Family Income Heterogeneity Analysis: Social participation has a stronger effect on cognitive function among higher-income individuals. Wealthier households have better access to diverse social networks and recreational activities, offering more opportunities for cognitive stimulation and emotional support (Smith et al., 2022; Zhu et al., 2023).
Urban-Rural Heterogeneity Analysis: While social participation benefits cognitive function in both urban and rural populations, the effect is stronger in rural areas. This may be due to limited access to educational resources, healthcare, and organized social activities in rural areas, making informal social interactions particularly vital for cognitive stimulation and emotional support. Moreover, rural life is relatively simpler, with fewer daily obligations and stronger social ties, allowing for more frequent interpersonal interactions. The prevalence of close-knit communities and familiar social circles increases opportunities for informal gatherings, fostering higher social participation, stronger emotional connections, and greater cognitive benefits (Harling et al., 2020).
To confirm the robustness of the regression results, several alternative specifications were employed (Table 6):
Model 1 - Substituting explanatory variables: Considering whether participation in social activities is also an effective variable for measuring the level of social activity participation, we elected to include participation in social activities as an explanatory variable for further validation. The promotional effect of social activity participation on cognitive abilities was confirmed through significance testing, demonstrating robust results.
Model 2 - Substituting response variables: Memory capacity was chosen as the response variable to further validate cognitive ability measurement. The regression coefficients remained significant, ensuring robustness of the study’s conclusions.
Model 3 - Sample selection: Samples with excessively low or high household incomes might influence the study. After excluding the top 10% and bottom 10% of household income samples, the coefficient for social activity participation passed significance testing, with all coefficients positive, indicating robust and reliable results.
Considering the potential endogeneity issues affecting the effect of social activity participation on cognitive abilities in middle-aged and elderly individuals, such issues could arise from measurement errors, omitted variables, and reverse causality. To address endogeneity, this study employed the instrumental variable (IV) approach, using the average level of social participation in other samples from the same city as instruments for social activity participation.
Wald test results (p = 0.000) confirm the presence of endogeneity. The first-stage IV regression (Table 7) shows that the instrument is strongly correlated with social participation (1% significance level). Cragg-Donald Wald F statistic results confirm that weak instrument bias is not an issue.
Table 8 presents the results of the mediation effect regression for depression level and grandchild care. Model 1 estimates the effect of social participation on grandchild care (Equation 2). Model 2 evaluates the combined effects of social participation and grandchild care on cognitive function (Equation 3). Model 3 examines the impact of social participation on depression (Equation 4). Model 4 assesses the joint effects of social participation and depression on cognitive function (Equation 5).
Model 1 indicates that social participation significantly increases grandchild caregiving engagement. Model 2 further reveals that both grandchild care and social participation positively impact cognitive function, suggesting that elderly individuals who actively engage in social activities are more likely to take on caregiving roles, which, in turn, may provide cognitive stimulation through intergenerational interactions.
However, it is important to note that although the mediation effect of grandchild care is statistically significant (p = 0.001), its effect size (β = 0.004) is relatively small. This suggests that, while caregiving offers cognitive engagement opportunities, its overall contribution as a mediator is limited. These findings align with Role Strain Theory, which posits that while caregiving can be cognitively stimulating, it may also impose stress and time burdens that counteract its benefits. Thus, caution should be exercised in interpreting its role as a key mediating factor.
Combining these with the results of the Sobel test, it can be inferred that grandchild care plays a partial mediating role in the relationship between social participation and cognitive function. That is, social participation not only has a direct positive impact on cognitive abilities but also indirectly enhances them through caregiving engagement. Despite its modest effect size, grandchild care remains an important form of social participation, fostering emotional fulfillment, intergenerational bonding, and cognitive engagement. Future research should explore how factors such as caregiving frequency, emotional strain, and the availability of family support influence the cognitive outcomes of caregiving. In contrast, depression appears to be a more substantial mediator in this relationship.
Regarding depression level, Model 3 illustrates that social participation exerts a significant inhibitory effect, exhibiting a negative correlation. Model 4 shows that social participation positively affects cognitive abilities, whereas depression level has a significant negative impact on them. This suggests that elderly individuals who participate in social activities tend to experience lower levels of depression. Social participation provides emotional support, fosters a sense of belonging, and reduces loneliness, all of which contribute to improved mental health and, subsequently, better cognitive outcomes.
Compared to grandchild care, depression demonstrates a stronger mediating effect (p = 0.001, β = –0.109), indicating that improving mental wellbeing may be a more critical pathway through which social participation enhances cognitive function. This aligns with the Cognitive Reserve Hypothesis, which suggests that reducing psychological distress can strengthen cognitive resilience by preserving neural function and delaying cognitive decline.
The Sobel test results provide evidence that social participation contributes to cognitive function improvements in the elderly through multiple mediation pathways. Among them, alleviating depression emerges as a more substantial mechanism compared to grandchild care. The detailed path coefficients and mediation model are illustrated in Figure 3.
The present study, through a combination of theoretical analysis and empirical testing, has reached the following conclusions: (i) Social participation has been demonstrated to exert a considerable positive influence on the cognitive function of middle-aged and elderly individuals, notably enhancing their cognitive abilities. Specifically, after controlling for various confounding variables, each additional type of social participation activity increases the cognitive function score by 0.417 points in middle-aged and elderly individuals. (ii) The impact of social participation on cognitive function exhibits heterogeneity. Overall, social participation positively affects middle-aged and elderly groups across different geographical regions, age cohorts, family income levels, and urban-rural living conditions. It is noteworthy that individuals residing in western regions, those aged 60 and above, higher-income groups, and rural elderly populations experience particularly pronounced benefits. (iii) Social participation indirectly affects cognitive function through two primary pathways: depression and grandchild caregiving. Increased social participation helps alleviate depressive symptoms, which in turn has a significant positive effect on cognitive function. This aligns with the Cognitive Reserve Hypothesis (Kremen et al., 2022), which suggests that engaging in social activities strengthens cognitive resilience by reducing psychological distress and promoting neuroprotective mechanisms. Compared to grandchild care, depression serves as a more substantial mediator, indicating that improvements in mental wellbeing may be a key mechanism linking social engagement to cognitive health. (iii) Although grandchild caregiving provides opportunities for cognitive engagement, its mediating effect is relatively modest. While social participation enhances the frequency of caregiving, its impact on cognitive function is limited in magnitude. According to Role Strain Theory (Hughes et al., 2007), caregiving responsibilities may impose psychological stress and time constraints, potentially counteracting the cognitive benefits of social participation. These findings highlight the dual role of caregiving, warranting further investigation into how factors such as caregiving intensity, emotional burden, and social support shape its impact on cognitive aging.
Overall, the results of this research confirm that social participation plays a critical role in maintaining cognitive function among middle-aged and elderly individuals. Nevertheless, the magnitude of its advantages varies among different population subgroups. “Vulnerable” groups, such as those residing in the central and eastern regions, middle-aged people, individuals with low-to-moderate incomes, and the urban elderly population, may encounter obstacles when attempting to access social engagement opportunities.
Middle-aged and elderly individuals should be encouraged and supported in actively engaging in social activities to enhance both the diversity and frequency of their participation. It is recommended that governments, communities, and families collaborate to provide a variety of social engagement opportunities, including interest groups, volunteer services, and cultural exchanges, in order to meet the diverse social needs of older adults.
Social participation strategies should be tailored to regional and demographic differences, considering variations in age, income level, and urban-rural residency. Particular attention should be given to individuals in central and eastern regions, those under 60 years old, low-income groups, and urban elderly populations, as these groups may face greater barriers to participation. Targeted interventions, such as community-based social programs and financial incentives, should be prioritized to ensure equitable access to social engagement opportunities.
Beyond promoting social participation, addressing mental health should be central to cognitive health interventions. Psychological counseling and social support services have been shown to alleviate depressive symptoms, thereby enhancing cognitive resilience. Given depression’s stronger mediating effect compared to grandchild caregiving, reducing social isolation and improving psychological wellbeing should be prioritized as key strategies for cognitive health preservation. Expanding community-based mental health programs and fostering multidisciplinary collaborations among policymakers and healthcare providers will ensure comprehensive and sustainable cognitive health interventions.
While grandchild caregiving is a form of social engagement, its cognitive benefits are context-dependent. Moderate caregiving may provide cognitive stimulation, but excessive responsibilities can induce stress, potentially offsetting these benefits. Thus, policies promoting caregiving should not assume universal cognitive advantages but rather consider the complexities of caregiving-related stress and time constraints. Future research should adopt longitudinal approaches to examine how grandchild caregiving intensity, emotional burden, and duration affect cognitive health. A more nuanced, evidence-based framework is needed to balance the cognitive benefits and potential psychological costs of grandchild caregiving, ensuring that intergenerational support policies promote both family wellbeing and cognitive longevity.
This study has several limitations. First, our analysis relies on self-reported measures, which may introduce reporting bias. Future research should incorporate objective cognitive assessments to validate our findings.
Second, despite employing robustness checks and instrumental variable analysis, the cross-sectional design limits causal inference. Future research should incorporate longitudinal studies and experimental interventions to establish a more definitive causal relationship.
Furthermore, although the mediation effect of grandchild care was statistically significant, its effect size was minimal. This may stem from the complexity of intergenerational caregiving and its varying influence on cognitive function. Additionally, the temporal mismatch in data sources, where grandchild care data were drawn from the CHARLS 2018, while other key variables were obtained from the CHARLS 2020 may have contributed to this result. While grandchild caregiving in China is generally stable over time, variations in caregiving intensity and involvement may not have been fully captured. Future studies should employ fully longitudinal datasets or time-series analyses to better understand the evolving impact of grandchild care on cognitive function.
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors.
The studies involving humans were approved by Peking University Biomedical Ethics Committee (IRB00001052-11015). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.
SZ: Conceptualization, Data curation, Formal Analysis, Methodology, Software, Validation, Writing – original draft, Writing – review and editing. ZZ: Conceptualization, Methodology, Project administration, Supervision, Writing – review and editing. TD: Conceptualization, Data curation, Validation, Writing – original draft. SS: Data curation, Methodology, Project administration, Supervision, Writing – review and editing.
The author(s) declare that financial support was received for the research and/or publication of this article. This study was funded by Foundation of Sichuan Research Center of Applied Psychology of Chengdu Medical College (CSXL-23404), the Primary Health Development Research Center of Sichuan Province Program (SWFZ23-Q-84), and the Deyang Science and Technology Program (2024SZS218).
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The authors declare that no Generative AI was used in the creation of this manuscript.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Barragán, A., Lucumí, D., and Lawlor, B. (2021). Association of leisure activities with cognitive impairment and dementia in older adults in Colombia: A SABE-based study. Front. Neurol. 12:629251. doi: 10.3389/fneur.2021.629251
Bourassa, K., Memel, M., Woolverton, C., and Sbarra, D. (2017). Social participation predicts cognitive functioning in aging adults over time: Comparisons with physical health, depression, and physical activity. Aging Ment. Health 21, 133–146. doi: 10.1080/13607863.2015.1081152
Brown, C., Gibbons, L., Kennison, R., Robitaille, A., Lindwall, M., Mitchell, M., et al. (2012). Social activity and cognitive functioning over time: A coordinated analysis of four longitudinal studies. J. Aging Res. 2012, 287438. doi: 10.1155/2012/287438
Chen, C., Tian, Y., Ni, L., Xu, Q., Hu, Y., and Peng, B. (2024). The influence of social participation and depressive symptoms on cognition among middle-aged and older adults. Heliyon 10:e24110. doi: 10.1016/j.heliyon.2024.e24110
Chopik, W. (2016). The benefits of social technology use among older adults are mediated by reduced loneliness. Cyberpsychol. Behav. Soc. Netw. 19, 551–556. doi: 10.1089/cyber.2016.0151
Coall, D., and Hertwig, R. (2010). Grandparental investment: Past, present, and future. Behav. Brain Sci. 33, 1–19. doi: 10.1017/S0140525x09991105
Di Tella, S., Cabinio, M., Isernia, S., Blasi, V., Rossetto, F., Saibene, F., et al. (2021). Neuroimaging biomarkers predicting the efficacy of multimodal rehabilitative intervention in the Alzheimer’s dementia continuum pathology. Front. Aging Neurosci. 13:735508. doi: 10.3389/fnagi.2021.735508
Du, Y., Luo, Y., Zheng, X., and Liu, J. (2023). Number of children and cognitive function among Chinese menopausal women: The mediating role of depressive symptoms and social participation. J. Affect. Disord. 340, 758–765. doi: 10.1016/j.jad.2023.08.084
Everly, J., Plummer, J., Lohman, M., and Neils-Strunjas, J. A. (2023). Tutorial for speech-language pathologists: Physical activity and social engagement to prevent or slow cognitive decline in older adults. Am. J. Speech Lang. Pathol. 32, 83–95. doi: 10.1044/2022_Ajslp-22-00035
Fabbri, L., Mosca, I., Gerli, F., Martini, L., Pancani, S., Lucidi, G., et al. (2018). The Games for older adults active life (GOAL) project for people with mild cognitive impairment and vascular cognitive impairment: A study protocol for a randomized controlled trial. Front. Neurol. 9:1040. doi: 10.3389/fneur.2018.01040
Fang, E., Scheibye-Knudsen, M., Jahn, H., Li, J., Ling, L., Guo, H., et al. (2015). A research agenda for aging in China in the 21st century. Ageing Res. Rev. 24, 197–205. doi: 10.1016/j.arr.2015.08.003
Fang, E., Xie, C., Schenkel, J., Wu, C., Long, Q., Cui, H., et al. (2020). A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res. Rev. 64:101174. doi: 10.1016/j.arr.2020.101174
Fu, C., Li, Z., and Mao, Z. (2018). Association between social activities and cognitive function among the elderly in China: A cross-sectional study. Int. J. Environ. Res. Public Health 15:231. doi: 10.3390/ijerph15020231
Gao, Y., Jia, Z., Zhao, L., and Han, S. (2023). The effect of activity participation in middle-aged and older people on the trajectory of depression in later life: National cohort study. JMIR Public Health Surveill. 9:e44682. doi: 10.2196/44682
George, K., Lutsey, P., Kucharska-Newton, A., Palta, P., Heiss, G., Osypuk, T., et al. (2020). Life-course individual and neighborhood socioeconomic status and risk of dementia in the atherosclerosis risk in communities neurocognitive study. Am. J. Epidemiol. 189, 1134–1142. doi: 10.1093/aje/kwaa072
Gu, S., Du, X., Han, D., Li, S., Zhao, J., Wu, Y., et al. (2024). The mediating roles of depressive symptoms and social participation in the relationship between the effects of pain and cognitive function among Chinese older adults: A longitudinal study. Geriatric Nursing. 57, 147–153. doi: 10.1016/j.gerinurse.2024.04.006
Harling, G., Kobayashi, L., Farrell, M., Wagner, R., Tollman, S., and Berkman, L. (2020). Social contact, social support, and cognitive health in a population-based study of middle-aged and older men and women in rural South Africa. Soc. Sci. Med. 260:113167. doi: 10.1016/j.socscimed.2020.113167
Hendriks, S., Peetoom, K., Bakker, C., van der Flier, W., Papma, J., Koopmans, R., et al. (2021). Global prevalence of young-onset dementia: A systematic review and meta-analysis. JAMA Neurol. 78, 1080–1090. doi: 10.1001/jamaneurol.2021.2161
Hou, X., Xiong, Y., Qiao, G., and Zhou, J. (2023). Association between caring for grandchildren based on living arrangements and cognitive function among Chinese middle-aged and older adults: The mediating roles of social activities and depressive symptoms. Front. Public Health 11:1105066. doi: 10.3389/fpubh.2023.1105066
Hughes, M., Waite, L., LaPierre, T., and Luo, Y. (2007). All in the family: The impact of caring for grandchildren on grandparents’ health. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 62, S108–S119. doi: 10.1093/geronb/62.2.S108
Kang, S., Lim, J., and Park, H. (2018). Relationship between low handgrip strength and quality of life in Korean men and women. Soc. Sci. Med. 27, 2571–2580. doi: 10.1007/s11136-018-1920-6
Kelly, M., Duff, H., Kelly, S., Power, J., Brennan, S., Lawlor, B., et al. (2017). The impact of social activities, social networks, social support and social relationships on the cognitive functioning of healthy older adults: A systematic review. Syst. Rev. 6:259. doi: 10.1186/s13643-017-0632-2
Kim, Y., and Lee, S. (2019). Social network types and cognitive decline among older Korean adults: A longitudinal population-based study. International J. Geriatric Psychiatry 34, 1845–1854. doi: 10.1002/gps.5200
Koczwara, A., Patterson, F., Zibarras, L., Kerrin, M., Irish, B., and Wilkinson, M. (2012). Evaluating cognitive ability, knowledge tests and situational judgement tests for postgraduate selection. Med. Educ. 46, 399–408. doi: 10.1111/j.1365-2923.2011.04195.x
Kremen, W., Elman, J., Panizzon, M., Eglit, G., Sanderson-Cimino, M., Williams, M., et al. (2022). Cognitive reserve and related constructs: A unified framework across cognitive and brain dimensions of aging. Front. Aging Neurosci. 14:834765. doi: 10.3389/fnagi.2022.834765
Lam, B., Haslam, C., Steffens, N., Yang, J., Haslam, S., Cruwys, T., et al. (2020). Longitudinal evidence for the effects of social group engagement on the cognitive and mental health of chinese retirees. J. Gerontol. Ser. B Psychol. Sci. Soc. Sci. 75, 2142–2151. doi: 10.1093/geronb/gbz134
Li, Y., Bai, X., and Chen, H. (2022). Social isolation, cognitive function, and depression among chinese older adults: Examining internet use as a predictor and a moderator. Front. Public Health 10:809713. doi: 10.3389/fpubh.2022.809713
Liao, S., Qi, L., Xiong, J., Yan, J., and Wang, R. (2021). Intergenerational ties in context: Association between caring for grandchildren and cognitive function in middle-aged and older Chinese. Int. J. Environ. Res. Public Health. 18:21. doi: 10.3390/ijerph18010021
Liu, Y., Liu, Z., Liang, R., and Luo, Y. (2022). The association between community-level socioeconomic status and cognitive function among Chinese middle-aged and older adults: A study based on the China Health and Retirement Longitudinal Study (CHARLS). BMC Geriatr. 22:239. doi: 10.1186/s12877-022-02946-3
Lv, X., Li, W., Ma, Y., Chen, H., Zeng, Y., Yu, X., et al. (2019). Cognitive decline and mortality among community-dwelling Chinese older people. BMC Med. 17:63. doi: 10.1186/s12916-019-1295-8
Ma, X., Piao, X., and Oshio, T. (2020). Impact of social participation on health among middle-aged and elderly adults: Evidence from longitudinal survey data in China. BMC Public Health 20:502. doi: 10.1186/s12889-020-08650-4
Mao, C., Li, Z., Lv, Y., Gao, X., Kraus, V., Zhou, J., et al. (2020). Specific leisure activities and cognitive functions among the oldest-old: The Chinese longitudinal healthy longevity survey. J. Gerontol. Biol. 75, 739–746. doi: 10.1093/gerona/glz086
Posis, A., Shadyab, A., Parada, H., Alcaraz, J., Kremen, W., and McEvoy, L. (2024). Multimorbidity, social engagement, and age-related cognitive decline in older adults from the rancho bernardo study of healthy aging. J. Alzheimers Dis. 97, 1689–1702. doi: 10.3233/Jad-230809
Rafael, A., Sousa, L., Martins, S., and Fernandes, L. (2021). Cognitive impairment in grandparents: A systematic review. Psychiatry Investig. 18, 593–602. doi: 10.30773/pi.2021.0034
Richards, M., James, S., Sizer, A., Sharma, N., Rawle, M., Davis, D., et al. (2019). Identifying the lifetime cognitive and socioeconomic antecedents of cognitive state: Seven decades of follow-up in a British birth cohort study. Bmj Open 9:e024404. doi: 10.1136/bmjopen-2018-024404
Samuel, P., Marsack, C., Johnson, L., LeRoy, B., Lysack, C., and Lichtenberg, P. (2017). Impact of grandchild caregiving on african American grandparents. Occup. Ther. Health Care 31, 1–19. doi: 10.1080/07380577.2016.1243821
Shah, H., Albanese, E., Duggan, C., Rudan, I., Langa, K., Carrillo, M., et al. (2016). Research priorities to reduce the global burden of dementia by 2025. Lancet Neurol. 15, 1285–1294. doi: 10.1016/S1474-4422(16)30235-6
Sheng, K., Chen, H., and Qu, X. (2024). The effects of cognitive leisure activities on frailty transitions in older adults in China: A CHARLS-based longitudinal study. BMC Public Health 24:1405. doi: 10.1186/s12889-024-18889-w
Shi, L., Tao, L., Chen, N., and Liang, H. (2023). Relationship between socioeconomic status and cognitive ability among Chinese older adults: The moderating role of social support. Int. J Equity Health 22:70. doi: 10.1186/s12939-023-01887-6
Shu, C., Zheng, C., Du, X., and Luo, D. (2024). Exploring the role of vitamin D in cognitive function: Mediation by depression with diabetes modulation in older US adults, a NHANES weighted analysis. Front. Nutr. 11:1356071. doi: 10.3389/fnut.2024.1356071
Shu, J., Qiang, Q., Yan, Y., Wen, Y., Ren, Y., Wei, W., et al. (2021). Distinct patterns of brain atrophy associated with mild behavioral impairment in cognitively normal elderly adults. Int. J. Med. Sci. 18, 2950–2956. doi: 10.7150/ijms.60810
Smith, L., Shin, J., Sanchez, G., Oh, H., Kostev, K., Jacob, L., et al. (2022). Social participation and mild cognitive impairment in low- and middle-income countries. Preventive Med. 164:107230. doi: 10.1016/j.ypmed.2022.107230
Su, X., Huang, X., Jin, Y., Wan, S., and Han, Z. (2018). The relationship of individual social activity and cognitive function of community Chinese elderly: A cross-sectional study. Neuropsychiatric Dis. Treatment 14, 2149–2157. doi: 10.2147/Ndt.S160036
Tarraf, W., Kaplan, R., Daviglus, M., Gallo, L., Schneiderman, N., Penedof, F., et al. (2020). Cardiovascular risk and cognitive function in middle-aged and older hispanics/latinos: Results from the hispanic community health study/study of latinos (HCHS/SOL). J. Alzheimers Dis. 73, 103–116. doi: 10.3233/Jad-190830
Van Bogart, K., Harrington, E., Witzel, D., Kang, J., Sliwinski, M., Engeland, C., et al. (2024). Momentary loneliness and intrusive thoughts among older adults: The interactive roles of mild cognitive impairment and marital status. Aging Ment Health 28, 1785–1792. doi: 10.1080/13607863.2024.2368643
Wang, G. (2023). Association of hearing impairment and cognitive impairment with all-cause mortality among the oldest-old Chinese people. Minerva Medica. Ear Hear. 44, 1212–1220. doi: 10.23736/S0026-4806.23.08707-4
Wang, J., Li, S., Hu, Y., Ren, L., Jiang, Y., Yu, M., et al. (2024). The bi-directional relationships between diversified leisure activity participation and cognitive function in older adults in China: Separating between-person effects from within-person effects. BMC Geriatr. 24:426. doi: 10.1186/s12877-024-04997-0
Wang, M., Sung, H., and Liu, J. (2022). Population aging and its impact on human wellbeing in China. Front. Public Health 10:883566. doi: 10.3389/fpubh.2022.883566
Wang, S., Li, S., and Hu, W. (2022). Grandparenting and subjective well-being in China: The moderating effects of residential location, gender, age, and income. Soc. Sci. Med. 315:115528. doi: 10.1016/j.socscimed.2022.115528
Wang, S., Lin, J., Kuang, L., Yang, X., Yu, B., and Cui, Y. (2024). Risk factors for social isolation in older adults: A systematic review and meta-analysis. Public Health Nurs. 41, 200–208. doi: 10.1111/phn.13266
Wang, Y., Dou, L., Wang, N., Zhao, Y., and Nie, Y. (2024). An analysis of factors influencing cognitive dysfunction among older adults in Northwest China based on logistic regression and decision tree modelling. BMC Geriatr. 24:405. doi: 10.1186/s12877-024-05024-y
Wilson, R., Scherr, P., Schneider, J., Tang, Y., and Bennett, D. (2007). Relation of cognitive activity to risk of developing Alzheimer disease. Neurology 69, 1911–1920. doi: 10.1212/01.wnl.0000271087.67782.cb
Xu, J., Wang, J., Wimo, A., Fratiglioni, L., and Qiu, C. (2017). The economic burden of dementia in China, 1990-2030: Implications for health policy. Bull World Health Organ. 95, 18–26. doi: 10.2471/BLT.15.167726
Xu, X., Xu, Y., and Shi, R. (2024). Association between obesity, physical activity, and cognitive decline in Chinese middle and old-aged adults: A mediation analysis. BMC Geriatr. 24:54. doi: 10.1186/s12877-024-04664-4
Yang, H., Zhang, S., Zhang, S., Wu, Y., and Luo, R. (2022). Fertility experiences and later-life cognitive function among older adults in China. Am. J. Hum. Biol. 34:e23786. doi: 10.1002/ajhb.23786
Zeng, Y., Chen, Y., and Lum, T. (2021). Longitudinal impacts of grandparent caregiving on cognitive, mental, and physical health in China. Aging Ment. Health 25, 2053–2060. doi: 10.1080/13607863.2020.1856779
Zhang, R., Shen, L., Miles, T., Shen, Y., Cordero, J., Qi, Y., et al. (2020). Association of low to moderate alcohol drinking with cognitive functions from middle to older derAge among US adults. JAMA Netw. Open 3:e207922. doi: 10.1001/jamanetworkopen.2020.7922
Zhao, Y., Hu, Y., Smith, J., Strauss, J., and Yang, G. (2014). Cohort profile: The China health and retirement longitudinal study (CHARLS). Int. J. Epidemiol. 43, 61–68. doi: 10.1093/ije/dys203
Keywords: cognitive function, social participation, middle-aged and elderly, grandchild care, depression, CHARLS, mediation effect study
Citation: Zhou S, Deng T, Shao S and Zeng Z (2025) The multiple mediating roles of depression and grandchild care in the relationship between social participation and cognitive function among middle-aged and elderly Chinese: an empirical study based on CHARLS 2020 data. Front. Aging Neurosci. 17:1549615. doi: 10.3389/fnagi.2025.1549615
Received: 21 December 2024; Accepted: 11 March 2025;
Published: 27 March 2025.
Edited by:
Valia Rodríguez-Rodríguez, Aston University, United KingdomReviewed by:
Akira Midorikawa, Chuo University, JapanCopyright © 2025 Zhou, Deng, Shao and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shirong Shao, MTg0MDgyNzA3NjhAMTYzLmNvbQ==; Zhi Zeng, OTQyNzY4MDgxQHFxLmNvbQ==
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Research integrity at Frontiers
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.