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ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1540168
This article is part of the Research Topic Mechanisms and Interventions for Enhancing Cognitive Reserve in Aging Populations View all 4 articles
Linking cognitive reserve to neuropsychological outcomes and resting-state frequency bands in healthy aging
Provisionally accepted- 1 Faculty of Health Sciences, Valencian International University, Valencia, Spain
- 2 University of Zaragoza, Zaragoza, Spain
- 3 University of Valencia, Valencia, Valencian Community, Spain
As the proportion of older people has surged in the past one hundred years, healthy aging has emerged as a crucial topic in neuroscience research. This study aimed to investigate the spectral power of EEG frequency bands during resting-state in older people with high and low cognitive reserve (CR). To do so, 74 healthy older people (55-74 years old) were recruited and divided into two groups based on their level of CR: high CR (n=41; 21 men and 20 women) and low CR (n=33; 15 men and 18 women). Both groups participated in a cognitive assessment and three minutes of EEG recording under resting-state conditions with eyes open (EO) and eyes closed (EC). EEG power was analyzed across four frequency bands: delta (0.1-<4 Hz), theta (4-<8 Hz), alpha1 (8-10 Hz), alpha2 (10-12), and beta (14-30 Hz), focusing on five cortical regions of interest.Neuropsychological tests did not reveal significant differences between the two groups on most of the cognitive measures. However, the EEG analysis showed that individuals with high CR exhibited lower spectral power in the theta and delta frequency bands across different brain regions, compared to those with low CR. These findings suggest that individuals with high CR tend to function more efficiently, relying on fewer neural resources to sustain cognitive performance. In contrast, those with low CR may engage compensatory neural mechanisms, as indicated by increased spectral power while resting, conceivably reflecting the brain's effort to preserve cognitive function.
Keywords: Electroencephalography, Frequency bands, Cognitive Reserve, healthy aging, neurological assessment
Received: 05 Dec 2024; Accepted: 04 Mar 2025.
Copyright: © 2025 Perez, Hidalgo and Salvador. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Vanesa Hidalgo, University of Zaragoza, Zaragoza, Spain
Alicia Salvador, University of Valencia, Valencia, 46010, Valencian Community, Spain
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