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ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1528527
Global Trends and Prospects of Ocular Biomarkers in Alzheimer's Disease: A Bibliometric Analysis
Provisionally accepted- Department of Neurology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China
Background: Alzheimer's disease (AD) diagnosis necessitates the development of novel biomarkers that ensure high diagnostic accuracy and cost-effectiveness in blood tests. Recent studies have identified a significant association between ocular symptoms and the pathological processes of AD, suggesting the potential for effective ocular biomarkers. This bibliometric analysis aims to explore recent advancements and research trends in ocular biomarkers for the early diagnosis of AD. Methods: Articles related to AD and ocular biomarkers were retrieved from the Web of Science Core Collection (WoSCC) database. These articles were analyzed using bibliometric tools such as VOSviewer, R-bibliometrix, and CiteSpace. Results: A total of 623 papers were included in the analysis, revealing a steady increase in publications since 2012. The United States produced the most publications, followed by China and Italy. Notably, authors affiliated with Complutense University of Madrid in Spain and Sapienza University of Rome in Italy made significant contributions, demonstrating robust internal collaborations. The Journal of Alzheimer's Disease published the most articles pertaining to ocular science and neuroscience. Keyword analysis indicates evolving trends in ocular markers for AD from 2005 to 2024, transitioning from diagnostic techniques (e.g.,"spectroscopy," "cerebrospinal fluid") to pathological mechanisms (e.g., "oxidative stress") and advanced imaging technologies (e.g., "optical coherence tomography angiography").The bibliometric analysis highlights key research hotspots related to ocular markers for AD, documenting the shift from basic diagnostic techniques to advanced imaging methods and the discovery of novel biomarkers. Future research may investigate the potential of Optical Coherence Tomography Angiography, tear component analysis, eye movement assessments, and artificial intelligence to enhance early detection of AD.
Keywords: Alzheimer's disease, Citespace, VOSviewer, bibliometric analysis, Ocular biomarkers
Received: 15 Nov 2024; Accepted: 05 Mar 2025.
Copyright: © 2025 Shen, Zhang, Xu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhuoying Zhu, Department of Neurology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.