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REVIEW article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1513049
Applications of Event-Related Potentials in Alzheimer's Disease ：Present Status and Prospects (a systematic review and analysis) Author names and affiliations
Provisionally accepted- 1Tongji University, Shanghai, China
- 2Department of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
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The prevalence of Alzheimer's disease (AD) has been increasing continuously, representing a major issue for public welfare. Detecting cognitive impairment due to AD at its early stages is an urgent prerequisite for therapeutic treatment to slow or halt disease progression before major brain damage occurs. Eventrelated potentials (ERPs) are a noninvasive neurophysiological technique with the advantages of objectivity, ease of operation, and real-time reflection of cognitive processing in the brain. ERPs are shown to play a crucial role in early diagnosis, disease monitoring, treatment effect evaluation and pathological mechanism research of AD. This article systematically reviews the recent ERPs-related studies of AD population, providing a comprehensive overview of present application status and prospects of ERPs in AD.(The purpose of this paper is to comprehensively assess the application value of ERP in AD. By systematically searching relevant literature in PubMed, Web of Science and Scopus databases, and merging and analyzing the literature included in the study, we explored the roles of various components of ERP in the diagnosis, disease monitoring and pathological mechanism research of AD, and provided a comprehensive overview of the current status and prospect of the application of ERP in AD.
Keywords: Alzheimer's disease, cognitive dysfunction, mild cognitive impairment (MCI), Event-related potentials, diagnosis, prediction
Received: 17 Oct 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Liang, Chen, Tang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xijin Wang, Department of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.