Qi Wu
Ju Peng Zhang
Lei Peng
Xiqi Zhu
*
Changhui Huang
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 |
doi: 10.3389/fnagi.2025.1498636
Imaging markers of cerebral small vessel disease are associated with Alzheimer's disease: A systematic review and meta-analysis
Provisionally accepted- Youjiang Medical University for Nationalities, Baise, China
Objective: This study aims to assess the correlation between cerebral small vessel disease (CSVD) imaging markers and Alzheimer's disease (AD) through metaanalyses.Methods: In July 2024, two researchers independently conducted a thorough literature search in databases such as PubMed, Embase, Web of Science, and the Cochrane Library. The selected studies investigated the correlations of white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), lacunar infarction (LI), and enlarged perivascular spaces (EPVS) with the risk of Alzheimer's disease (AD). The Newcastle-Ottawa Scale (NOS) was employed to assess the risk of bias in the cohort and case-control studies included in this analysis.Results: A total of 6487 articles were identified and 15 articles met criteria for inclusion.
Keywords: Cerebral small vessel disease, Alzheimer's disease, Imaging markers, metaanalysis, Magnetic Resonance Imaging
Received: 19 Sep 2024; Accepted: 06 Jan 2025.
Copyright: © 2025 Wu, Zhang, Peng, Zhu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiqi Zhu, Youjiang Medical University for Nationalities, Baise, China
Changhui Huang, Youjiang Medical University for Nationalities, Baise, China
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