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REVIEW article
Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1468895
This article is part of the Research Topic Common pathophysiology underpinning Parkinson's disease and other neurodegenerative diseases View all 14 articles
Advances in autonomic dysfunction research in Parkinson's disease
Provisionally accepted- Department of Neurology, The Second Hospital of Shandong University, Jinan, China
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, best known for its motor symptoms such as resting tremor, muscle rigidity, and bradykinesia. However, autonomic dysfunction is an important non-motor aspect that often brings considerable discomfort and distress to both patients and their families. In this review, we summarize recent advances in understanding the pathophysiological mechanisms of autonomic dysfunction and explore its relationship with other clinical features. Our aim is to discover novel potential diagnostic and therapeutic strategies, alleviate patient suffering, and pave the way for future clinical and basic research.
Keywords: Parkinson's disease, autonomic dysfunction, review, Motor symptoms, non-motor symptoms
Received: 22 Jul 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Xu, Zheng, Xing, Bi, Wang, Zhang, Wei and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shunliang Xu, Department of Neurology, The Second Hospital of Shandong University, Jinan, China
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