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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1529639
This article is part of the Research Topic Lifestyle and Environmental Influences on Alzheimer's Disease: Exploring the Roles of Diet, Exercise, Cognitive Reserve, Sleep, and Air Quality View all 14 articles

Threshold effects of sleep duration and cognitive function in older adults with BMI ≥ 25 kg/m 2

Provisionally accepted
Kunyu Qiu Kunyu Qiu 1,2Yilei Liu Yilei Liu 1Chengwei Hu Chengwei Hu 1Jie Gu Jie Gu 2YAN YAN HUANG YAN YAN HUANG 2*
  • 1 Putuo District Changzheng Town Community Health Service Center, Shanghai, China
  • 2 Department of General Medicine, Huashan Hospital, Fudan University, Shanhai, China

The final, formatted version of the article will be published soon.

    Background: It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and cognitive decline remains a subject of debate. The impact of sleep duration on cognitive performance in seniors with a body mass index (BMI) ≥ 25kg/m 2 is largely unknown. This makes it an intriguing subject to explore further.Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES) (2011-2014) with 2,243 participants. Weighted multivariate linear regression and smooth curve fitting were employed to investigate linear and non-linear relationships. A two-part linear regression model was used to determine the threshold effects. Additionally, subgroup analysis and interaction tests were conducted.Results showed that a negative association was found between sleep duration and scores in the fully adjusted model in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). A two-piecewise linear regression model was then applied to explore the threshold effect of sleep duration on cognitive performance. When sleep duration was less than 5 and 6 hours per day, sleep duration was positively correlated with CERAD test scores [ß (95% CI): 2.11 (1.17, 3.05), p < 0.0001], AFT scores [β (95% CI): 0.25 (-0.17, 0.67), p = 0.2376], and DSST scores [ß (95% CI): 0.49 (-0.57, 1.56), p = 0.3654]. However, there was a threshold effect where sleep duration reached the three inflection points.In overweight and obese older adults, there is a clear inverted U-shaped relationship between sleep duration and cognitive function, with consistent results across different subgroups. Sleep durations of around 5-6 hours may help prevent cognitive decline in older adults with a BMI ≥ 25 kg/m².

    Keywords: Cognitive Function, Overweight, Obesity, sleep duration, NHANES

    Received: 17 Nov 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Qiu, Liu, Hu, Gu and HUANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: YAN YAN HUANG, Department of General Medicine, Huashan Hospital, Fudan University, Shanhai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.