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REVIEW article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1517965
This article is part of the Research Topic Current Chemical Approaches in Combating Neuroinflammation in Alzheimer's Disease (AD) View all 4 articles

Mitochondrial Dysfunction and Alzheimer's disease: Pathogenesis of mitochondrial transfer

Provisionally accepted
Yun Wei Yun Wei *Xinlei Du Xinlei Du Hongling Guo Hongling Guo Jingjing Han Jingjing Han Meixia Liu Meixia Liu *
  • Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

The final, formatted version of the article will be published soon.

    In recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes.Alzheimer's disease (AD) is a multifactorial disease, with mitochondrial dysfunction at its core. Although numerous studies have found evidence of mitochondrial transfer in AD models, the precise mechanisms remain unclear. Recent studies have revealed the dynamic transfer of mitochondria in Alzheimer's disease, not only between nerve cells and glial cells, but also between nerve cells and glial cells. In this review, we explore the pathways and mechanisms of mitochondrial transfer in Alzheimer's disease and how these transfer activities contribute to disease progression.

    Keywords: Alzheimer's disease, Mitochondrial transfer, Mitochondrial dysfunction, Neuroprotection, AD treatment

    Received: 27 Oct 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Wei, Du, Guo, Han and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yun Wei, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    Meixia Liu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.