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MINI REVIEW article

Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1492449
This article is part of the Research Topic CSF-Blood Brain Barriers in Neurodegenerative Diseases View all articles

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

Provisionally accepted
Birra Rissa Taha Birra Rissa Taha 1Cornelius Hoktsim Lam Cornelius Hoktsim Lam 1,2*
  • 1 University of Minnesota Health Sciences, University of Minnesota Medical Center, Minneapolis, United States
  • 2 Minneapolis VA Health Care System, Veterans Health Administration, United States Department of Veterans Affairs, Minneapolis, Minnesota, United States

The final, formatted version of the article will be published soon.

    In this review, we explore the mechanisms of the blood-cerebrospinal fluid (CSF) barrier and CSF transport. We briefly review the mathematical framework for CSF transport as described by a set of well-studied partial differential equations. Moreover, we describe the major contributors of CSF flow through both diffusive and convective forces beginning at the molecular level and extending into macroscopic clinical observations. In addition, we review neurosurgical perspectives in understanding CSF outflow pathways. Finally, we discuss the implications of flow dysregulation in the context of neurodegenerative diseases and discuss the rising role of perivascular drainage pathways including glymphatics.

    Keywords: CSF (cerebrospinal fluid), Hydrocephalus, Alzheimer's disease, Choroid Plexus, Endoscopic third ventnculostomy (ETV)

    Received: 06 Sep 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Taha and Lam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Cornelius Hoktsim Lam, University of Minnesota Health Sciences, University of Minnesota Medical Center, Minneapolis, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.