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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1489185
This article is part of the Research Topic Recent advances in research on cognitive frailty and related conditions View all 15 articles

A study of the correlation between sarcopenia and cognitive impairment in older individuals over 60 years: cross-sectional and longitudinal validation

Provisionally accepted
Xiaohan Dong Xiaohan Dong Yichao Yu Yichao Yu Jiahao Li Jiahao Li Xinyu Chai Xinyu Chai *Wei Shan Wei Shan Huiping Yan Huiping Yan *Yifan Lu Yifan Lu *
  • Beijing Sport University, Beijing, China

The final, formatted version of the article will be published soon.

    Objective: To validate the correlation between sarcopenia and cognition, and explore cognitive subdomains affected by sarcopenia.: A case-control study was designed to recruit 90 individuals aged 60 and above from June to October 2023 in the same community, all individuals meeting the inclusion criteria were categorized according to the 2019 Asian criteria for sarcopenia and divided into the sarcopenia group and non-sarcopenia group at baseline. After a 12-week follow-up recording, individuals were classified into the aggravation group and alleviation group based on the change of sarcopenia severity. Sarcopenia tests including muscle mass, calf circumference, grip strength and physical function assessment, using Montreal Cognitive Assessment (MoCA) of nine dimensions for cognitive assessment.Results: 1) There was a significant positive correlation between cognitive function and grip strength in males (r = 0.42, p < 0.05). 2) There was a moderate correlation between sarcopenia grading and MoCA score (r = -0.4, p < 0.001). 3) Individuals with sarcopenia had significantly lower MoCA total scores and sub-scores in executive function, fluency, calculation and delayed recall compared to non-sarcopenia group (p < 0.05).4) After 12 weeks, the mean value of the change in fluency in the alleviation group increased by 0.33 points, while the aggravation group decreased by 0.2 points (W = 128, p < 0.05).There is a correlation between sarcopenia and cognitive function, individuals with sarcopenia performing poorly in overall cognition as well as refined dimensions. The degree of cognition like fluency degenerates over time with increasing severity of sarcopenia.

    Keywords: Sarcopenia, Cognitive Function, aging frailty, fluency, Memory

    Received: 31 Aug 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Dong, Yu, Li, Chai, Shan, Yan and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xinyu Chai, Beijing Sport University, Beijing, China
    Huiping Yan, Beijing Sport University, Beijing, China
    Yifan Lu, Beijing Sport University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.