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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1487182
This article is part of the Research Topic Recent advances in research on cognitive frailty and related conditions View all 11 articles

Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease

Provisionally accepted
Feilong Wu Feilong Wu 1Jie Pan[Author] Jie Pan[Author] 1,2Mingtao Chen Mingtao Chen 1Xuye Lai Xuye Lai 1Yingying Gu Yingying Gu 1Lei Pei Lei Pei 1Lili Yang Lili Yang 1*
  • 1 School of Public Health, Sun Yat-sen University, Guangzhou, China
  • 2 Changzhou Center for Disease Control and Prevention, Changzhou, China

The final, formatted version of the article will be published soon.

    This study investigated the potential link between serum klotho levels and cognitive function in patients with non-alcoholic fatty liver disease (NAFLD). Utilizing NHANES data from 2011 to 2014, the research included 356 eligible participants. NAFLD was identified with the United States Fatty Liver Index (US-FLI), and cognition was measured by various tests including the Animal Fluency Test (AFT), Digit Symbol Substitution Test (DSST), Immediate Recall Test (IRT), and Delayed Recall Test (DRT). Weighted logistic regression and restricted cubic splines were employed to analyze the relationship between klotho levels and cognitive scores. A significant nonlinear association was observed between klotho levels and the performance in DSST and Delayed Recall Test (DRT). After controlling for confounding factors, the study found a positive association between higher serum klotho levels and improved cognitive performance in both AFT and DSST. However, there was no significant relationship between klotho levels and the IRT or DRT, regardless of whether the natural logarithm or quartile was considered. The findings suggest that a higher serum klotho level may be positively correlated with better cognitive performance in NAFLD patients.

    Keywords: NAFLD, Klotho, cognitive performance, DSST, AFT

    Received: 27 Aug 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wu, Pan[Author], Chen, Lai, Gu, Pei and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lili Yang, School of Public Health, Sun Yat-sen University, Guangzhou, China

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