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PERSPECTIVE article

Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1482922
This article is part of the Research Topic Similarities and Differences Between Cellular and Molecular Mechanisms of Normal Brain Aging and Neurodegeneration View all articles

Rejuvenation factor PF4: A potential gatekeeper for neurodegenerative diseases

Provisionally accepted
Fengju Jia Fengju Jia *
  • Qingdao University, Qingdao, China

The final, formatted version of the article will be published soon.

    Recently, it is discovered PF4 is a cognitive enhancer that improved the cognitive abilities of younger mice and gave older animals their middle-aged acuity back. PF4 works by reducing inflammation during the aging process. As we all known, aging is undoubtedly the main risk factor of neurodegenerative diseases. Furthermore, inflammation has been extensively investigated and attracted even more interest. Therefore, the aim of the proposal is to highlight the worth of PF4 in inflammaging of neurodegenerative diseases, which might provide a potential therapeutic strategy.

    Keywords: PF4, Neurodegenerative Diseases, Aging, Neuroinflammation, Parinson's disease

    Received: 19 Aug 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fengju Jia, Qingdao University, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.