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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1480171

Efficacy of high-frequency rTMS in the treatment of gait disorder and cognition in patients with Parkinson's disease based on wearable devices and eye-movement assessments

Provisionally accepted
Hong Yin Tang Hong Yin Tang 1,2XiangLian Liao XiangLian Liao 3,4Peng Li Peng Li 5Pengfei ZHANG Pengfei ZHANG 6Jian Yao Jian Yao 3,4Xing Yilan Xing Yilan 4Xin Zhao Xin Zhao 4Xuying He Xuying He 4*Jie Zan Jie Zan 7*GUIHUA LI GUIHUA LI 4*
  • 1 The Third People's Hospital of Baiyun District, Guangzhou, Guangdong, China
  • 2 The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, China
  • 3 Southern Medical University, Guangzhou, China
  • 4 Department of Neurology, the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China
  • 5 Department of Anesthesiology and Surgery, Liwan Central Hospital of Guangzhou, Guangzhou, China
  • 6 Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China
  • 7 School of Biomedical and Pharmaceutical sciences, Guangdong University of Technology, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Postural instability and gait disorder and cognitive dysfunction are common symptoms of Parkinson's disease (PD). Scale assessment is frequently used in the clinic to evaluate PD, but this technique is limited by its lack of sensitivity to changes in disease progression and its difficulty in capturing subtle movements and changes in cognitive function. It is currently believed that high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve motor and cognitive dysfunction in patients with PD, though it remains controversial. Therefore, it is imperative to monitor and dynamically identify changes in postural instability and gait disorder, as well as those in cognitive dysfunction, in PD to develop targeted interventions. In this study, we observed the effect of high-frequency rTMS on gait disorders and cognitive functions in patients with PD by comparing data from wearable devices and eye-tracking devices before and after treatment.

    Keywords: Parkinson's disease, wearable gait analyzer, eye movement assessments, Gait disorder, Cognition

    Received: 14 Aug 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Tang, Liao, Li, ZHANG, Yao, Yilan, Zhao, He, Zan and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xuying He, Department of Neurology, the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China
    Jie Zan, School of Biomedical and Pharmaceutical sciences, Guangdong University of Technology, Guangzhou, 510006, Guangdong Province, China
    GUIHUA LI, Department of Neurology, the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.