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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1466089

Association between blood pressure and dementia in older adults: A cross-sectional study from China

Provisionally accepted
Tingting Yi Tingting Yi 1,2,3Su Zhou Su Zhou 3Jiyang Wang Jiyang Wang 1,2,4Jinghuan Gan Jinghuan Gan 5Hao Wu Hao Wu 2Zhihong Shi Zhihong Shi 2Zhen Sun Zhen Sun 6Shuai Liu Shuai Liu 2yong Ji yong Ji 7*
  • 1 Tianjin Medical University, Tianjin, Tianjin Municipality, China
  • 2 Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China
  • 3 The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China
  • 4 People's Hospital Of Qingxian, Cangzhou, China
  • 5 Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 6 Linfen Central Hospital, Linfen, Shanxi Province, China
  • 7 Tianjin Huanhu Hospital, Tianjin, China

The final, formatted version of the article will be published soon.

    The association between blood pressure (BP) and dementia in older adults remains unclear, prompting this study to investigate the relationship between various BP indicators and dementia in this population.A cross-sectional survey was conducted in 2019, including 3599 participants aged 65 years or older. The basic demographic characteristics of participants were collected. BP measurements and neuropsychological assessments were performed. From the systolic BP (SBP) and diastolic BP (DBP) values, mean arterial pressure (MAP), pulse pressure (PP) and blood pressure index (BPI) were calculated. Generalized additive models and logistic regression models were used to analyze the association between BP indicators and dementia.Results: Generalized additive models identified a U-shaped relationship between DBP and dementia, which was more significant in males and people 70 years of age and older. The optimal DBP associated with the lowest dementia risk was 85 mmHg.Logistic regression models revealed that compared to the DBP subgroup (80-89 mmHg), participants in the DBP < 80 mmHg subgroup and the DBP ≥100 mmHg subgroup had OR for dementia of 1.611 (95% CI: 1. 252-2.073, P ＜ 0.001) and 1.423 (95% CI: 0.999-2.028, P = 0.050), respectively. A significant association was observed between BPI and dementia (OR:1.746 95% CI: 1.142-2.668, P = 0.010).In older adults, we found a U-shaped relationship between DBP and dementia, and a linear relationship between BPI and dementia. These results underscore the importance of considering DBP and BPI in BP management strategies for older adults to potentially prevent or delay dementia onset.

    Keywords: Blood pressure index, Dementia, Diastolic blood pressure, older adults, U-shaped association

    Received: 17 Jul 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Yi, Zhou, Wang, Gan, Wu, Shi, Sun, Liu and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: yong Ji, Tianjin Huanhu Hospital, Tianjin, China

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