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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1460241
This article is part of the Research Topic Recent advances in research on cognitive frailty and related conditions View all 10 articles

Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Hormone Levels in Early Stroke Patients with Low Thyroid Hormone Levels

Provisionally accepted
Hong Li Hong Li 1,2*Jiang Ma Jiang Ma 1,2*Zi-Qiang Song Zi-Qiang Song 3,4Xiao-Lin Tao Xiao-Lin Tao 1,2Yan Xing Yan Xing 1Feng Zhang Feng Zhang 5
  • 1 Shijiazhuang People’s Hospital, Shijiazhuang, China
  • 2 Department of Rehabilitation Medicine, Shijiazhuang, Hebei Province, China
  • 3 College of Physical Education, Hebei Normal University, Shijiazhuang, Hebei Province, China
  • 4 Physical Education College, Hebei Normal University, Shijiazhuang, China, Shijiazhuang, Hebei Province, China
  • 5 Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, China., Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Background: This study aimed to observe the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function and thyroid hormone levels in early older stroke patients with low thyroid hormone levels, and to investigate the correlation between the changes in thyroid hormone levels and the improvements in cognitive function after stroke. scores in the rTMS group were statistically higher than those in the Sham group at the end of the 4-week intervention and at the follow-up (P<0.05); The changes in the levels of T3 before and after 4-week intervention were positively correlated with the changes in the MoCA scores (r=0.638, P<0.05). And the difference in T3 level change was positively correlated with the difference in delayed recall, attention and naming score change (r=0.562, P<0.05; r=0.562, P<0.05; r=0.531, P<0.05); and the difference in FT3 level change was positively correlated with the visuospatial and executive function (r=0.514, P<0.05). Conclusion: Repetitive transcranial magnetic stimulation improved cognitive function and elevated T3 levels in older patients with post-stroke cognitive dysfunction who had low thyroid hormone levels. Within the normal range, increases in T3 levels are positively correlated with changes in cognitive function.

    Keywords: Stroke, repetitive transcranial magnetic stimulation, Thyroid hormone, Cognitive Function, HPT axis, Rehabilitation

    Received: 05 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Li, Ma, Song, Tao, Xing and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hong Li, Shijiazhuang People’s Hospital, Shijiazhuang, China
    Jiang Ma, Department of Rehabilitation Medicine, Shijiazhuang, Hebei Province, China

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