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REVIEW article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1459025

The Role of PI3K Signaling Pathway in Alzheimer's Disease

Provisionally accepted
Yankai Wang Yankai Wang Qi Yao Qi Yao Chenlong Li Chenlong Li *Yongjiang Wu Yongjiang Wu Jingying Pan Jingying Pan Jianhong Shen Jianhong Shen *Riyun Yang Riyun Yang *
  • Nantong University, Nantong, China

The final, formatted version of the article will be published soon.

    Alzheimer's disease (AD) is a debilitating progressively neurodegenerative disease. The best-characterized hallmark of AD, which is marked by behavioral alterations and cognitive deficits, is the aggregation of deposition of amyloid-beta (Aβ) and hyper-phosphorylated microtubule-associated protein Tau. Despite decades of experimental progress, the control rate of AD remains poor, and more precise deciphering is needed for potential therapeutic targets and signaling pathways involved. In recent years, phosphoinositide 3-kinase (PI3K) and Akt have been recognized for their role in the neuroprotective effect of various agents, and glycogen synthase kinase 3 (GSK-3), a downstream enzyme, is also crucial in the tau phosphorylation and Aβ deposition. An overview of the PI3K/Akt pathway's function in the pathophysiology of AD is provided in this review, along with a discussion of recent developments in the pharmaceuticals and herbal remedies that target the PI3K/Akt signaling pathway. In conclusion, despite the challenges and hurdles, cumulative findings of novel targets and agents in the PI3K/Akt signaling axis are expected to hold promise for advancing AD prevention and treatment.

    Keywords: Alzheimer's disease, PI3K, tau protein, amyloid-β, Akt, GSK3

    Received: 03 Jul 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Wang, Yao, Li, Wu, Pan, Shen and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chenlong Li, Nantong University, Nantong, China
    Jianhong Shen, Nantong University, Nantong, China
    Riyun Yang, Nantong University, Nantong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.