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REVIEW article

Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1454282
This article is part of the Research Topic CSF Clearance in Alzheimer's Disease and Related Dementias: Exploring Mechanisms and Implications View all 4 articles

The Impact of Body Position on Neurofluid Dynamics: Present Insights and Advancements in Imaging

Provisionally accepted
Marco Muccio Marco Muccio 1Zhe Sun Zhe Sun 1David Chu David Chu 2Brianna Damadian Brianna Damadian 2Lawrence Minkoff Lawrence Minkoff 2Luciano Bonanni Luciano Bonanni 2Yulin Ge Yulin Ge 1*
  • 1 Department of Radiology, Grossman School of Medicine, New York University, New York, United States
  • 2 Fonar Corporation (United States), Melville, New York, United States

The final, formatted version of the article will be published soon.

    The intricate neurofluid dynamics and balance is essential in preserving the structural and functional integrity of the brain. Key among these forces are: hemodynamics, such as heartbeat-driven arterial and venous blood flow, and hydrodynamics, such as cerebrospinal fluid (CSF) circulation. The delicate interplay between these dynamics is crucial for maintaining optimal homeostasis within the brain. Currently, the widely accepted framework for understanding brain functions is the Monro-Kellie's doctrine, which posits a constant sum of intracranial CSF, blood flow and brain tissue volumes. However, in recent decades, there has been a growing interest in exploring the dynamic interplay between these elements and the impact of external factors, such as daily changes in body position.CSF circulation in particular plays a crucial role in the context of neurodegeneration and dementia, since its dysfunction has been associated with impaired clearance mechanisms and accumulation of toxic substances. Despite the implementation of various invasive and noninvasive imaging techniques to investigate the intracranial hemodynamic or hydrodynamic properties, a comprehensive understanding of how all these elements interact and are influenced by body position remains wanted. Establishing a comprehensive overview of this topic is therefore crucial and could pave the way for alternative care approaches.In this review, we aim to summarize the existing understanding of intracranial hemodynamic and hydrodynamic properties, fundamental for brain homeostasis, along with factors known to influence their equilibrium. Special attention will be devoted to elucidating the effects of body position shifts, given their significance and remaining ambiguities. Furthermore, we will explore recent advancements in imaging techniques utilized for real time and noninvasive measurements of dynamic body fluid properties in-vivo.

    Keywords: neurofluids dynamics, Aging, neurodegeneration, body position effects, Neuroimaging, phase contrast MRI

    Received: 24 Jun 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Muccio, Sun, Chu, Damadian, Minkoff, Bonanni and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yulin Ge, Department of Radiology, Grossman School of Medicine, New York University, New York, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.