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REVIEW article

Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1453710

c-Jun N-terminal Kinase Signaling in Aging

Provisionally accepted
Yihao Li Yihao Li 1Li You Li You 2Eugenie Nepovimova Eugenie Nepovimova 3Vojtech Adam Vojtech Adam 4Zbyněk Heger Zbyněk Heger 4Klaudia Jomova Klaudia Jomova 5Marian Valko Marian Valko 6Qinghua Wu Qinghua Wu 1Kamil Kuca Kamil Kuca 3*
  • 1 Yangtze University, Jingzhou, Hubei Province, China
  • 2 School of Physical Education and Health, Chongqing University of International Business and Economics, Chongqing, China
  • 3 University of Hradec Králové, Hradec Králové, Czechia
  • 4 Mendel University in Brno, Brno, South Moravia, Czechia
  • 5 Constantine the Philosopher University, Nitra, Nitra, Slovakia
  • 6 Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia

The final, formatted version of the article will be published soon.

    Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities.However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process, remain insufficiently understood.Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. Moreover, the circadian rhythm protein is implicated in JNK-mediated aging. Through this comprehensive review, we meticulously elucidate the intricate regulatory mechanisms orchestrated by JNK signaling in aging processes, offering unprecedented molecular insights with significant implications and highlighting potential therapeutic targets. We also explore the translational impact of targeting JNK signaling for interventions aimed at extending healthspan and promoting longevity.

    Keywords: JNK, Aging, molecular insights, therapeutic targets, longevity studied(Gavia-Garcia et al., 2021)

    Received: 23 Jun 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Li, You, Nepovimova, Adam, Heger, Jomova, Valko, Wu and Kuca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kamil Kuca, University of Hradec Králové, Hradec Králové, Czechia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.