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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1452766
This article is part of the Research Topic A comprehensive look at biomarkers in neurodegenerative diseases: from early diagnosis to treatment response assessment View all 16 articles

Associations of Motor and Neuropsychiatric Symptoms with Comorbidities in Prodromal Parkinson's Disease

Provisionally accepted
Jia-Ru Chen Jia-Ru Chen 1Yan Sun Yan Sun 1Yu-Ju Ma Yu-Ju Ma 1Lan Tan Lan Tan 1,2*
  • 1 Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China., Qingdao, China
  • 2 Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the associations between comorbidities and multimorbidity patterns with motor and neuropsychiatric symptoms in patients with Parkinson's disease (PD) in prodromal PD.Methods: Multimorbidity is defined as the coexistence of two or more long-term conditions (LTCs) (also known as multiple comorbidities). A total of 921 participants without PD were included in the Parkinson's Progression Markers Initiative (PPMI) database and were categorized according to the LTC count. Participants were evaluated on motor and psychiatric symptoms. Pearson correlation to examine relationship of comorbidities and target symptoms. The baseline population was analyzed using Multiple linear regression model, while mixed effects model was utilized for longitudinal analysis. Fuzzy C-means clustering analysis was conducted to identify comorbidity patterns, followed by multiple linear regression for further analysis.Results: At baseline, a higher LTC count was significantly correlated with more severe motor (MDS-UPDRS Ⅰ, Ⅱ, ADL, all P < 0.05) and neuropsychiatric symptoms (QUIP, P<0.001). Three multimorbidity patterns were identified. Among them, the cardiometabolic multimorbidity pattern (CAR) had the most significant correlation with the aforementioned symptoms. Our longitudinal analysis indicated that an increase in the LTC count was associated with the exacerbation of motor and neuropsychiatric symptoms.Comorbidities were cross-sectionally and longitudinally associated with the motor and neuropsychiatric symptoms of patients with prodromal PD. Among the three multimorbidity patterns, CAR posed the highest threat to the risk of more severe motor and neuropsychiatric symptoms.

    Keywords: Comorbidity, multimorbidity, Parkinson's disease, Motor symptoms, Neuropsychiatry symptoms, Multimorbidity patterns

    Received: 21 Jun 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Chen, Sun, Ma and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lan Tan, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.