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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1450337
This article is part of the Research Topic Neurobiological insights into healthy brain aging: From molecular markers to behavioral manifestations – A cross-species analysis View all articles

An integrated transcriptomic investigation into brain aging and solutions for healthy aging

Provisionally accepted
Haiying Liu Haiying Liu 1*Xin Nie Xin Nie 2Fengwei Wang Fengwei Wang 1Dandan Chen Dandan Chen 1Zhuo Zeng Zhuo Zeng 1PENG SHU PENG SHU 2Junjiu Huang Junjiu Huang 1
  • 1 Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
  • 2 Shenzhen Hujia Technology Co.,Ltd, Shenzhen, China

The final, formatted version of the article will be published soon.

    It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands as a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common aging genes across organs or tissues, and whether these aging genes play a pivotal role in the development of age-related diseases.In this study, we screened for aging genes using RNAseq data of 32 human tissues from GTEx. RNAseq datasets from GEO were used to study whether aging genes drives age-related diseases, or whether anti-aging solutions could reverse aging gene expression.Results: Aging transcriptome alterations showed that brain aging differ significantly from the rest of the body, furthermore, brain tissues were divided into four group according to their aging transcriptome alterations. Numerous genes were downregulated during brain aging, with functions enriched in synaptic function, ubiquitination, mitochondrial translation and autophagy. Transcriptome analysis of age-related diseases and retarding aging solutions showed that downregulated aging genes in the hippocampus further downregulation in Alzheimer's disease but were effectively reversed by high physical activity. Furthermore, the neuron loss observed during aging was reversed by high physical activity.The downregulated of many genes is the major factor of brain aging and neurodegeneration, and high physical activity is an effective way to re-activate their expression, making it a potentially effective solution for retarding brain aging.

    Keywords: Aging gene, Brain aging, Neurodegenerative Diseases, Retard aging, Transcriptome

    Received: 17 Jun 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Liu, Nie, Wang, Chen, Zeng, SHU and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Haiying Liu, Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

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