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REVIEW article

Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1446523

Mechanisms Underlying Delirium in Patients with Critical Illness

Provisionally accepted
Yingying Fan Yingying Fan 1Ruoyu Luo Ruoyu Luo 1Mengtian Wang Mengtian Wang 2Chaoyun Yuan Chaoyun Yuan 2Yuanyuan Sun Yuanyuan Sun 2Jiyong Jing Jiyong Jing 2*
  • 1 Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
  • 2 Zhejiang Provincial People's Hospital, Hangzhou, China

The final, formatted version of the article will be published soon.

    Delirium is an acute, global cognitive disorder syndrome, also known as acute brain syndrome, characterized by disturbance of attention and awareness and fluctuation of symptoms. Its incidence is high among critically ill patients.Once patients develop delirium, it increases the risk of unplanned extubation, prolongs hospital stay, increases the risk of nosocomial infection, post-intensive care syndrome-cognitive impairment, and even death.Therefore, it is of great importance to understand how delirium occurs and to reduce the incidence of delirium in critically ill patients.This paper reviews the potential pathophysiological mechanisms of delirium in critically ill patients, with the aim of better understanding its pathophysiological processes, guiding the formulation of effective prevention and treatment strategies, providing a basis for clinical medication.

    Keywords: Delirium1, Critical illness2, Cognition impairment3, Mechanism4, Review5 Conceptualization,Investigation,Interpretation of data,Writing &Revising draft,Draw a figure, Author LRY:Conceptualization,Investigation,Writing -Original Draft, Author WMT:Conceptualization,Investigation,Writing -Original Draft, Author YCY:Conceptualization,Investigation,Revising draft, Author SYY:Conceptualization,Investigation,Draw a figure, Conceptualization,Supervision, Writing -Review & Editing

    Received: 10 Jun 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Fan, Luo, Wang, Yuan, Sun and Jing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiyong Jing, Zhejiang Provincial People's Hospital, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.