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SYSTEMATIC REVIEW article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1444716

The Impact of Physical Exercise on Neuroinflammation Mechanism in Alzheimer's Disease

Provisionally accepted
  • 1 West Anhui University, Lu'an, Anhui, China
  • 2 Yunnan Nationalities University, Kunming, Yunnan Province, China
  • 3 Tianjin University of Sport, Tianjin, China

The final, formatted version of the article will be published soon.

    Alzheimer's disease (AD) is a principal cause of dementia worldwide, significantly impacting societal and personal costs. This review consolidates findings from recent studies on physical exercise as a nonpharmacological intervention to modulate neuroinflammation and enhance neuronal function in AD. Reviews indicate that regular physical exercise modifies neuroinflammatory pathways, improves cognitive function, and promotes brain health in AD patients. It positively affects microglial and astrocytic activation states, reinforces blood-brain barrier integrity, and reduces AD-related gut inflammation. These mechanisms are linked to notable improvements in cognitive metrics and brain health biomarkers, advocating for the integration of exercise into comprehensive AD management strategies. Highlighting the need for ongoing research, this review calls for refining exercise regimens to optimize their long-term benefits in slowing AD progression.

    Keywords: Alzheimer's disease, physical exercise, Neuroinflammation, microglial activation, Blood-brain barrier integrity

    Received: 21 Jun 2024; Accepted: 07 Aug 2024.

    Copyright: © 2024 Hu, Huang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Baiqing Huang, Yunnan Nationalities University, Kunming, 650031, Yunnan Province, China
    Kang Chen, Tianjin University of Sport, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.