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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1437278
This article is part of the Research Topic A comprehensive look at biomarkers in neurodegenerative diseases: from early diagnosis to treatment response assessment View all 6 articles

Identification of deregulated lncRNAs in Alzheimer's disease: an integrated gene co-expression network analysis of hippocampus and fusiform gyrus RNAseq datasets

Provisionally accepted
Ermes Filomena Ermes Filomena 1Ernesto Picardi Ernesto Picardi 1Apollonia Tullo Apollonia Tullo 2Graziano Pesole Graziano Pesole 1Anna M. D'Erchia Anna M. D'Erchia 1,3*
  • 1 Department of Biosciences, Biotechnologies, and Environment, University of Bari Aldo Moro, Bari, Italy
  • 2 Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, Department of Biomedical Sciences, National Research Council (CNR), Bari, Apulia, Italy
  • 3 University of Bari Aldo Moro, Bari, Italy

The final, formatted version of the article will be published soon.

    Introduction: The deregulation of lncRNAs expression has been associated with neuronal damage in Alzheimer’s disease (AD), but how or whether they can influence its onset is still unknown. We investigated 2 RNA-seq datasets consisting, respectively, of the hippocampal and fusiform gyrus transcriptomic profile of AD patients, matched with non-demented controls. Methods: We performed a differential expression analysis, a gene correlation network analysis (WGCNA) and a pathway enrichment analysis of two RNA-seq datasets. Results: We found deregulated lncRNAs in common between hippocampus and fusiform gyrus and deregulated gene groups associated to functional pathways related to neurotransmission and memory consolidation. LncRNAs, co-expressed with known AD-related coding genes, were identified from the prioritized modules of both brain regions. Discussion: We found common deregulated lncRNAs in the AD hippocampus and fusiform gyrus, that could be considered common signatures of AD pathogenesis, providing an important source of information for understanding the molecular changes of AD.

    Keywords: Alzheimer's disease, RNA-Seq, Differentially expressed genes, lncRNAs, WGCNA

    Received: 23 May 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Filomena, Picardi, Tullo, Pesole and D'Erchia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anna M. D'Erchia, University of Bari Aldo Moro, Bari, Italy

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