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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1423875
This article is part of the Research Topic Advances in Parkinson's Disease Research: Exploring Biomarkers and Therapeutic Strategies for Halting Disease Progression View all 14 articles

P1 Evoked by Facial Expression Images is Enhanced in Parkinson's disease patients with depressive symptoms

Provisionally accepted
Yujia Sun Yujia Sun Mo Luo Mo Luo Chunkai Peng Chunkai Peng Qingqing Li Qingqing Li Zhuyong Wang Zhuyong Wang Sha Xue Sha Xue *Shizhong Zhang Shizhong Zhang *
  • Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Introduction: Depressive symptoms are most common non-motor symptoms in Parkinson's disease (PD), which is often overlooked due to absence of rapid and objective diagnostic biomarkers. Electroencephalography (EEG)-based event-related potentials (ERPs) is commonly used to assess emotional processes. The aim of this study was to investigate changes in ERPs in PD patients exhibiting depressive symptoms and to provide a reliable biomarker for assisting in the diagnosis of PD with depressive symptoms.Methods: We conducted a case-control study involving 30 PD patients with (dPD group) or without depressive symptoms (nPD group) and 13 age matched healthy controls (HC). We recorded EEG of the patients during the emotional picture stimulation task and analyzed the difference in the early ERPs potentials (P1, N170, early posterior negativity) and their correlation with the severity of symptoms in PD patients.Results: Our results found that P1 amplitude in the occipital region of the dPD group in response to emotional faces was significantly higher than that of nPD and HC group, and it was positively correlated with severity of depressive symptoms in PD patients.Our study shows that facial expression-induced enhancement of P1 amplitude can be utilized as a rapid and objective indicator to screen for depressive symptoms in PD.

    Keywords: Parkinson's disease, Event Related Potentials, depressive disorders, P1, biomarker

    Received: 26 Apr 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Sun, Luo, Peng, Li, Wang, Xue and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sha Xue, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    Shizhong Zhang, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.