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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1423707
This article is part of the Research Topic Gut Beyond Gut: The Gut-Brain Axis View all articles

The involvement of Effector Memory CD4 + T cells in mediating the impact of genus Oscillibacter gut microbiota on Alzheimer's disease: a Mendelian randomization study

Provisionally accepted
Huachang Zhang Huachang Zhang 1Yudong Wang Yudong Wang 1Hui Zhao Hui Zhao 2Wei Wang Wei Wang 3Fabin Han Fabin Han 1*
  • 1 Liaocheng People's Hospital, Liaocheng, China
  • 2 Henan Academy of Sciences Henan High tech Industrial Co. Ltd, Henan, China
  • 3 The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng People's Hospital/Liaocheng University, Liaocheng, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to investigate the causal relationship between gut microbiota characteristics (207 taxa and 205 pathways) and Alzheimer's disease , and to determine and quantify the role of immune cells as potential mediators.Methods: Gut microbiota characteristics (207 taxa and 205 pathways) were obtained from the NHGRI-EBI GWAS Catalog project, while Alzheimer's disease data and 731 immune cell characteristics were obtained from the IEU Open GWAS project. Two-sample Mendelian randomization (MR) was conducted to determine whether gut microbiota characteristics (207 taxa and 205 pathways) were causally related to Alzheimer's disease. Furthermore, two-step MR was employed to quantify the proportion of the effect of immune cell characteristics mediated by gut microbiota characteristics (207 taxa and 205 pathways) on Alzheimer's disease.Results: 17 immune cell characteristics were identified as potential mediators for 13 gut microbiota influencing Alzheimer's disease, with Effector Memory CD4+ T cell Absolute Count accounted for 8.99% of the causal relationship between genus Oscillibacter and Alzheimer's disease.In summary, our research confirms a causal relationship between gut microbiota and Alzheimer's disease, with immune cells contributing to a significant portion of the effect. However, the full mediators of gut microbiota's impact on Alzheimer's disease remains unclear.Further investigation is warranted to explore additional potential risk factors acting as mediators.

    Keywords: Mendelian Randomization Analysis, Gut Microbiota, Alzheimer's disease, immune cells, GWAS

    Received: 26 Apr 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Zhang, Wang, Zhao, Wang and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fabin Han, Liaocheng People's Hospital, Liaocheng, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.