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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1422772

Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE Study

Provisionally accepted
An-Yi Wang An-Yi Wang He-Ying Hu He-Ying Hu Yan Sun Yan Sun Ya-nan Ou Ya-nan Ou Ya-Hui Ma Ya-Hui Ma Meng Li Meng Li Qiongyao Li Qiongyao Li Lan Tan Lan Tan *
  • Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China

The final, formatted version of the article will be published soon.

    Increasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O3], nitrogen dioxide [NO2], and particulate matter [PM2.5]) with CSF α-syn levels in urban older adults. We included 933 urban participants from the Chinese Alzheimer's Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF αsyn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (CHD) were performed. Moreover, restricted cubic spline (RCS) models were applied to explore the potential nonlinear relationships. We found a significant correlation of CSF α-syn level with PM2.5 in urban participants. Specifically, multiple linear regression showed a significant negative association between PM2.5 and CSF α-syn level (p = 0.029), which was more significant in female, midlife, non-CHD, and cold season subgroups. Besides, RCS models showed that O3 had an inverse J-shaped association with CSF α-syn levels in urban participants (p for nonlinearity = 0.040), and the harmful effect possibly appeared when O3 was above 37.9 ppb. Long-term exposure to air pollution was associated with lower CSF α-syn levels, which may offer a new direction for exploring and preventing synucleinopathies.

    Keywords: Air Pollution, alpha-Synuclein, Cerebrospinal Fluid, synucleinopathies, Association

    Received: 24 Apr 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Wang, Hu, Sun, Ou, Ma, Li, Li and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lan Tan, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China

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