AUTHOR=Li Shangjie , He Xiuping , Wu Liang , Tang Xinming , Ouyang Yijiang , Jing Wenyuan , Yang Ya , Yang Jiacheng , Che Kechun , Pan Congcong , Chen Xiaoting , Zhang Xiaoxia , Zheng Xueting , Xu Jiahao , Liao Shaobin , Yin Mingjuan , Ni Jindong 

TITLE=The association of cognitive function and its changes with all-cause mortality among community-dwelling older adults

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=16

YEAR=2024

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2024.1419235

DOI=10.3389/fnagi.2024.1419235

ISSN=1663-4365

ABSTRACT=<sec><title>Background</title><p>The association of cognitive function, its changes, and all-cause mortality has not reached a consensus, and the independence of the association between changes in cognitive function and mortality remains unclear. The purpose of this study was to evaluate the longitudinal association between baseline cognitive function and cognitive changes over 1 year with subsequent all-cause mortality among the older adults aged 60 and above.</p></sec><sec><title>Methods</title><p>A prospective cohort study utilizing the Community Older Adults Health Survey data. Initiated in 2018, the study annually assessed all individuals aged 60+ in Dalang Town, Dongguan City. Cognitive function was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). A total of 6,042 older adults individuals were included, and multivariate Cox proportional hazard models were used to examine cognitive function’s impact on mortality.</p></sec><sec><title>Results</title><p>Participants’ median age was 70 years, with 39% men. Over a median 3.08-year follow-up, 525 died. Mortality risk increased by 6% per MMSE score decrease (adjusted <italic>HR</italic> = 1.06, 95%<italic>CI</italic>: 1.05–1.08). Compared to those with normal cognitive function at baseline, participants with mild cognitive impairment and moderate to severe cognitive impairment had significantly higher mortality risks (adjusted <italic>HR</italic> = 1.40, 95%<italic>CI</italic>: 1.07–1.82; <italic>HR</italic> = 2.49, 95%<italic>CI</italic>: 1.91–3.24, respectively). The risk of death was 5% higher for each one-point per year decrease in cognitive function change rate (<italic>HR</italic> = 1.05, 95%CI: 1.02–1.08). Compared with participants with stable cognitive function, those with rapid cognitive decline had a 79% increased risk of death (adjusted <italic>HR</italic> = 1.79, 95% <italic>CI</italic>: 1.11–2.87), with baseline cognitive function influencing this relationship significantly (<italic>P</italic> for interaction = 0.002).</p></sec><sec><title>Conclusion</title><p>Baseline cognitive impairment and rapid cognitive decline are associated with higher all-cause mortality risks in Chinese older adults. Baseline function influences the mortality impact of cognitive changes.</p></sec>