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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1415494

The Role of Serum α-Klotho Levels in Preventing Hearing Impairment among Middle-aged and Older Adults: Insights from a Nationally Representative Sample

Provisionally accepted
Siyuan Wang Siyuan Wang Wen Sun Wen Sun Chan Ding Chan Ding Wenxin Zhou Wenxin Zhou Min Zhang Min Zhang Huadong Xu Huadong Xu *
  • Hangzhou Medical College, Hangzhou, China

The final, formatted version of the article will be published soon.

    The Klotho gene is implicated in suppressing aging phenotypes and influencing age-related diseases. Previous studies have delved into its connection with different diseases, yet the association between Klotho and hearing loss has rarely been examined. A recent population study explored the relationship between serum Klotho and hearing loss, but it had certain limitations. This study aims to analyze the link between serum α-Klotho levels and hearing thresholds, as well as the risk of hearing loss.Methods: A total of 1762 adults aged 40-69 years were selected from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). Data on audiometry, serum α-Klotho levels, and relevant covariates were gathered. Statistical analyses, including linear and logistic regression, assessed the relationships of serum α-Klotho levels with hearing outcomes.Results: Increased serum α-Klotho levels were correlated with diminished hearing thresholds and a lower risk of hearing loss. Quartile analysis revealed a significant trend, where elevated α-Klotho levels were linked to better auditory outcomes.Adjusted models controlled for various covariates, affirming the robustness of the findings. Non-linear associations were not observed.This study provided novel evidence of a negative association between serum α-Klotho and hearing impairment in adults aged 40-69. Our results suggested a protective role of serum α-Klotho on adults with hearing loss.

    Keywords: Klotho, adults, Hearing thresholds, Hearing Loss, restricted cubic splines

    Received: 10 Apr 2024; Accepted: 24 Oct 2024.

    Copyright: © 2024 Wang, Sun, Ding, Zhou, Zhang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huadong Xu, Hangzhou Medical College, Hangzhou, China

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