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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1412542

Association of Peak Expiratory Flow with Motoric Cognitive Risk Syndrome among Older Adults

Provisionally accepted
Hui Xu Hui Xu 1*Xiangwen Gong Xiangwen Gong 2Kaiwang Cui Kaiwang Cui 2,3Xuerui Li Xuerui Li 1,4Long Chen Long Chen 5Yiyi Lu Yiyi Lu 2Yangfang Liao Yangfang Liao 2Jianping Liu Jianping Liu 2
  • 1 Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China, Beijing, China
  • 2 The Fifth People’s Hospital of Ganzhou, Ganzhou, China
  • 3 Department of Hepatology, Ganzhou Key Laboratory of Liver Diseases, Ganzhou Institute of Respiratory Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi Province, China, Ganzhou, Jiangxi Province, China
  • 4 Tianjin Medical University General Hospital, Tianjin, China
  • 5 Gannan Medical University, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    The association between lung function and motoric cognitive risk syndrome (MCR) is unclear. We aimed to explore the association of peak expiratory flow (PEF) with MCR using cross-sectional and longitudinal analyses.Methods: Within the CHARLS, 5095 participants were included in the cross-sectional analysis, and 4340 MCR-free participants were included in the longitudinal analysis. The PEF was assessed with a lung peak flow meter. MCR was characterized by cognitive complaints and a slow walking speed with normal mobility and without dementia. Logistic regression, Cox regression, and Laplace regression models were employed for data analysis.In this cross-sectional study, logistic regression analyses revealed that continuous PEF was associated with MCR (odds ratio [OR], 0.998; 95% confidence interval [CI], 0.998, 0.999), and the ORs (95% CIs) of MCR prevalence were 0.857 (0.693, 1.061) for the middle tertile and 0.665 (0.524, 0.845) for the highest tertile compared to the lowest tertile. In a longitudinal cohort study, continuous PEF was dose-dependently associated with the risk of MCR. Compared with those in the lowest tertile of PEF, the hazard ratios (95% CIs) of incident MCR were 0.827 (0.661, 1,036) for the middle tertile and 0.576 (0.432, 0.767) for the highest tertile. Furthermore, compared with the lowest tertile, the highest tertile was associated with a delayed onset time of MCR of 0.484 (95% CI: 0.151, 0.817) years.Conclusions: A higher PEF was related to a lower prevalence of MCR and a lower risk for MCR, and a higher PEF also prolonged the onset time of MCR.

    Keywords: Motoric cognitive risk syndrome, Peak expiratory flow, older adults, Lung function, cohort study

    Received: 05 Apr 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Xu, Gong, Cui, Li, Chen, Lu, Liao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Xu, Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.