AUTHOR=Wen Xin , Song Shangrong , Tian Hui , Cui Hang , Zhang Lijuan , Sun Yajie , Li Mingyue , Wang Yonghong 

TITLE=Intervention of computer-assisted cognitive training combined with occupational therapy in people with mild cognitive impairment: a randomized controlled trial

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=16

YEAR=2024

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2024.1384318

DOI=10.3389/fnagi.2024.1384318

ISSN=1663-4365

ABSTRACT=<sec id="sec1"><title>Objective</title><p>Investigate the impact of combined computerized cognitive training and occupational therapy on individuals with mild cognitive impairment (MCI).</p></sec><sec id="sec2"><title>Methods</title><p>We randomly assigned 118 MCI patients into two groups: a combined intervention group (<italic>n</italic> = 37) and a control group (<italic>n</italic> = 81), the latter receiving standard nursing care. The intervention group additionally underwent 12 weeks of computerized cognitive training and occupational therapy. Blind assessors evaluated cognitive performance, anxiety, depression, and daily living activities before the intervention, post-intervention, and at a 3-month follow-up.</p></sec><sec id="sec3"><title>Results</title><p>Repeated-measures analysis of variance showed that the sMoCA scores, HAMA scores, and ADL scores of the experimental group at T2 (post-intervention) and T3 (3-month follow-up) were higher than those of the control group, and the difference was statistically significant (<italic>p</italic> &lt; 0.001, <italic>p</italic> &lt; 0.001, <italic>p</italic> = 0.026).</p></sec><sec id="sec4"><title>Conclusion</title><p>Computerized cognitive training combined with occupational therapy can improve patients’ cognitive status, enhance their compliance with continuing care, and maintain their anxiety and self-care ability at a stable level.</p></sec><sec><title>Clinical trial registration</title><p><ext-link xlink:href="https://www.chictr.org.cn/index.html" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.chictr.org.cn/index.html</ext-link>, identifier ChiCTR2200065014.</p></sec>