This article is a correction to:
Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson’s disease
Zhi-ting Chen1†
Chu-zhui Pan2,3†Xing-lin Ruan1†Li-ping Lei2,3Sheng-mei Lin2,3
Yin-zhou Wang2,3*
Zhen-Hua Zhao2,3*- 1Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China
- 2Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China
- 3Department of Neurology, Fujian Provincial Hospital, Fuzhou, Fujian, China
A corrigendum on
Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease
by Chen, Z.-t., Pan, C.-z., Ruan, X.-l., Lei, L.-p., Lin, S.-m., Wang, Y.-z., and Zhao, Z.-H. (2023). Front. Aging Neurosci. 15:1216905. doi: 10.3389/fnagi.2023.1216905
In the published article “Chawla, S., Gulyani, S., Allen, RP., Earley, C.J., Li, X., Van, Zijl. P., et al. (2019). Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome. Sleep 42, zsz079. 10.1093/sleep/zsz079” was not cited in the article. The citation has now been inserted in introduction, Paragraph 5 and should read:
“Studies of iron and iron-related proteins levels in cerebrospinal fluid (CSF), serum, plasma, and urine have shown conflicting results. Meta-analyses of these studies have revealed that CSF and serum/plasma ferritin and transferrin concentrations did not differ significantly between PD patients and controls (Jimenez-Jimenez et al., 2021). However, recent studies have shown that exosomes were a pathway for neurons to divert proteins from neurons into the CSF or into the peripheral blood via the blood-brain barrier (Shi et al., 2014). Exosomal a-synuclein in neural-derived blood exosomes was found to be increased in patients with PD (Shi et al., 2016). Chalwa's group studied the iron homeostasis in restless legs syndrome, and found that the patients had higher levels of total ferritin and heavy-chain ferritin, and similar levels of TfR in serum neural-derived exosomes (Chawla et al., 2019). To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
In the published article, there was an error. Chawla's team has made pioneering work on the study of iron metabolism in blood neuro-exosomes, although the patients in their study were RLS, but not PD. There are some of the expressions in our original article are not rigorous enough.
A correction has been made to abstract, introduction. This sentence previously stated:
“While the blood of healthy animals contains a plentiful supply of TfR positive exosomes, no studies have examined ferritin and TfR in plasma neuralderived exosomes.”
The corrected sentence appears below:
“While the blood of healthy animals contains a plentiful supply of TfR positive exosomes, rare study has examined ferritin and TfR in plasma neural-derived exosomes in PD.”
The other correction has been made to introduction, Paragraph 5. This sentence previously stated:
“To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
The corrected sentence appears below:
“Chalwa's group studied the iron homeostasis in restless legs syndrome, and found that the patients had higher levels of total ferritin and heavy-chain ferritin, and similar levels of TfR in serum neural-derived exosomes (Chawla et al., 2019). To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
In the published article, there was an error in “Figure 3. Comparation of ferritin and TfR in PD and controls, and ROC analysis of biomarkers for PD diagnosis” as published. In Figure 3A and 3B, “PD” and “control” was reversed by mistake. The corrected “Figure 3. Comparation of ferritin and TfR in PD and controls, and ROC analysis of biomarkers for PD diagnosis” and its caption appear below. In Figure 3A and 3B, “PD” and “control” swapped positions.
Figure 3
Figure 3. Comparation of ferritin and TfR in PD and controls, and ROC analysis of biomarkers for PD diagnosis. The box plots showed the comparison of the levels of ferritin (A) and TfR (B) in the two groups. *, P < 0.01. In the whole cohort, ferritin in plasma neural-derived exosomes provided an AUC of 0.73 (sensitivity = 67.4%, specificity = 79.4%) for PD versus controls (C). TfR performed similarly (AUC = 0.812, sensitivity = 86.0%, specificity = 70.6%) in the whole cohort (D). And, the combination of ferritin and TfR did not obviously improve the performance with AUC of 0.808 (sensitivity = 86.0%, specificity = 73.5%) (E).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
References
Chawla, S., Gulyani, S., Allen, RP., Earley, C.J., Li, X., Van Zijl, P., et al. (2019). Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome. Sleep 42, zsz079. doi: 10.1093/sleep/zsz079
Jimenez-Jimenez, F. J., Alonso-Navarro, H., Garcia-Martin, E., and Agundez, J. A. G. (2021). Biological fluid levels of iron and iron-related proteins in Parkinson's disease: Review and meta-analysis. Eur. J. Neurol. 28, 1041–1055. doi: 10.1111/ene.14607
Shi, M., Kovac, A., Korff, A., Cook, T. J., Ginghina, C., Bullock, K. M., et al. (2016). CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimers Dement. J. Alzheimers Assoc. 12, 1125–1131. doi: 10.1016/j.jalz.2016.04.003
Keywords: biomarker, ferritin, transferrin receptor, exosome, Parkinson's disease
Citation: Chen Z-t, Pan C-z, Ruan X-l, Lei L-p, Lin S-m, Wang Y-z and Zhao Z-H (2024) Corrigendum: Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease. Front. Aging Neurosci. 15:1355200. doi: 10.3389/fnagi.2023.1355200
Received: 13 December 2023; Accepted: 29 December 2023;
Published: 19 January 2024.
Edited and reviewed by: Robert Petersen, College of Medicine, Central Michigan University, United States
Copyright © 2024 Chen, Pan, Ruan, Lei, Lin, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yin-zhou Wang, wphd@163.com; Zhen-Hua Zhao, 30470353@qq.com
†These authors have contributed equally to this work