AUTHOR=Liu Ning , Wang Lingxing TITLE=An approach for assisting diagnosis of Alzheimer's disease based on natural language processing JOURNAL=Frontiers in Aging Neuroscience VOLUME=15 YEAR=2023 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2023.1281726 DOI=10.3389/fnagi.2023.1281726 ISSN=1663-4365 ABSTRACT=Introduction

Alzheimer's Disease (AD) is a common dementia which affects linguistic function, memory, cognitive and visual spatial ability of the patients. Language is proved to have the relationship with AD, so the time that AD can be diagnosed in a doctor's office is coming.

Methods

In this study, the Pitt datasets are used to detect AD which is balanced in gender and age. First bidirectional Encoder Representation from Transformers (Bert) pretrained model is used to acquire the word vector. Then two channels are constructed in the feature extraction layer, which is, convolutional neural networks (CNN) and long and short time memory (LSTM) model to extract local features and global features respectively. The local features and global features are concatenated to generate feature vectors containing rich semantics, which are sent to softmax classifier for classification.

Results

Finally, we obtain a best accuracy of 89.3% which is comparative compared to other studies. In the meanwhile, we do the comparative experiments with TextCNN and LSTM model respectively, the combined model manifests best and TextCNN takes the second place.

Discussion

The performance illustrates the feasibility to predict AD effectively by using acoustic and linguistic datasets.